Results 71 to 80 of about 2,541 (192)
Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report
SAGE Open Medical Case Reports, 2020 Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this disease is caused by the subspecies Trypanosoma brucei gambiense .
Berthe Amélie Iroungou +5 more
doaj +1 more source
Journal of Nanotechnology, Volume 2026, Issue 1, 2026.The limited efficacy and toxicity of benznidazole in the chronic stage of Chagas disease highlight the need for alternative and complementary therapeutic strategies. To expand current knowledge, the present study explores the mechanism of action of Cymbopogon densiflorus essential oil and its combination with benznidazole in micellar systems as a ...
Janaína Brandão Seibert +12 more
wiley +1 more source
, 2015 This study aimed to characterize the stereoselective pharmacokinetics of oral eflornithine in 25 patients with late-stage Trypanosoma brucei gambiense sleeping sickness.
Jansson-Löfmark, R +9 more
core +1 more source
, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914) +2 more
core +1 more source
Ball‐Milling Assisted Iron‐Catalyzed Difluoromethylation Toward the Synthesis of Valuable Oxindoles
ChemSusChem, Volume 18, Issue 24, December 13, 2025.An iron‐catalyzed difluoroalkylation of acrylamides under ball‐milling conditions affords oxindoles in up to 85% yield. Analytical studies reveal that the apparent piezoelectric activity originates from iron leaching caused by milling assembly abrasion during the reaction process. The iron‐catalyzed process proves to be efficient with a broad substrate
Vitalii Solomin +4 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.ABSTRACT Background While human skin aging involves complex transcriptional alterations, the cell‐type‐specific regulatory mechanisms and therapeutic targets remain incompletely defined. The study aims to investigate aging‐associated transcriptional programs and drug‐responsive signatures at single‐cell resolution.
Youcheng Zhang +4 more
wiley +1 more source
, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914) +2 more
core +1 more source
Cancer Science, Volume 116, Issue 11, Page 3079-3089, November 2025.Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Xue‐Chen Wei +7 more
wiley +1 more source
Analysis of eflornithine and nifurtimox on T. brucei growth.
, 2012 A) The effects of trypanostatic drugs in combination with nifurtimox. White points show the drugs in combination, black points show the drugs in isolation.
Isabel M. Vincent (167717) +5 more
core +1 more source