Results 51 to 60 of about 1,936 (110)

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

SAGE Open Medical Case Reports, 2020
Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this disease is caused by the subspecies Trypanosoma brucei gambiense .
Berthe Amélie Iroungou, Larson Boundenga, Laurette Guignali Mangouka, Berthold Bivigou-Mboumba, Jean Raymond Nzenze, Gael Darren Maganga   +5 more
doaj   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis

The Journal of Pathology, Volume 265, Issue 1, Page 26-40, January 2025.
Abstract Patients with familial adenomatous polyposis (FAP) harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. There is no validated treatment, and animal models are not sufficient to study FAP. Our aim was to investigate the early events associated with FAP using the intestinal organoid model in a single‐center ...
Nolwenn Laborde, Alexandre Barusseaud, Muriel Quaranta, Corinne Rolland, Amélie Arrouy, Delphine Bonnet, Sylvain Kirzin, Nuria Sola‐Tapias, Dimitri Hamel, Karl Barange, Jean‐Pierre Duffas, Marie‐Pierre Gratacap, Julie Guillermet‐Guibert, Anne Breton, Nathalie Vergnolle, Laurent Alric, Audrey Ferrand, Frédérick Barreau, Claire Racaud‐Sultan, Emmanuel Mas   +19 more
wiley   +1 more source

Dermatological care of gender‐diverse patients in Australia

Australasian Journal of Dermatology, Volume 65, Issue 8, Page 601-609, December 2024.
Abstract In recent years, there has been an increasing recognition of the unique healthcare needs of gender‐diverse patients in Australia. With the continuous growth of referrals to gender health services, there is an increased demand for specialised dermatological care.
Roy Kingsley Wong, Jenny Harrington, Annabel Irene Stevenson   +2 more
wiley   +1 more source

Effets de la difluorométhylornithine après administration intraveineuse et son association avec de l'acéturate de diminazène contre Trypanosoma bruceichez des chiens infectés expérimentalement au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1997
De la difluorométhylornithine (DFMO, eflornithine) a été donnée par voie intraveineuse (lV) à des chiens infectés expérimentalement par Trypanosoma brucei.
B.M. Anene, S.M. Anika, C.C. Chukwu
doaj   +1 more source

Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents

Archiv der Pharmazie, Volume 357, Issue 10, October 2024.
Hydrazinated geraniol derivatives were synthesised and tested in vitro against different parasitic protozoans of clinical relevance, including Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania infantum. Compounds 6, 8, 13, 14 and 15 demonstrated low micromolar activity against the different parasites.
Joelien Jooste, Lesetja J. Legoabe, Kayhan Ilbeigi, Guy Caljon, Richard M. Beteck   +4 more
wiley   +1 more source

ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape. [PDF]

Cell Death Dis
Metabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Tao H, Wang X, Hu Z, Li Y, Kong M, Sun Y, Gao K, Wan X.   +7 more
europepmc   +2 more sources

Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer's Disease: A Compassionate Use, Single-Case Study

Frontiers in Aging Neuroscience, 2018
Background: Recent genome-wide association screening (GWAS) studies have linked Alzheimer's disease (AD) neuropathology to gene networks that regulate immune function. Kan et al.
Jessica Alber, Jessica Alber, Kelly McGarry, Richard B. Noto, Peter J. Snyder, Peter J. Snyder, Peter J. Snyder   +6 more
doaj   +1 more source

Transforming Pediatric Oncology Research: The Role of Collaboration, Precision Medicine, and Evolving Study Designs

Pediatric Blood &Cancer, Volume 72, Issue 3, March 2025.
Shyam Srinivasan
wiley   +1 more source