Results 51 to 60 of about 2,541 (192)
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications
Taiwanese Journal of Obstetrics & Gynecology, 2022 Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism.
Rumaisa Rashid +7 more
doaj +1 more source
, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914) +2 more
core +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.Herein, we report a photocatalyst‐free hydrodifluoromethylation of alkenes using Zn(CF2H)2(DMPU)2 and thiophenols under 390 nm irradiation. The thiophenol serves a dual stoichiometric function, promoting the formation of a photoactive thiol‐modified organozinc species while acting as the terminal hydrogen‐atom donor.
Hyunsu Kim, Seonyoung Kim, Hyunwoo Kim
wiley +1 more source
PLoS Neglected Tropical Diseases, 2018 We conducted a retrospective study on mortality trends and risk factors in 781 naïve cases of advanced stage-2 sleeping sickness admitted between 1989 and 2012 at the National Reference Center for Human African Trypanosomiasis (HAT), Department of ...
Léon Mbiyangandu Kazumba +3 more
doaj +1 more source
PLoS ONE, 2020 BACKGROUND:The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy.
Gaber El-Saber Batiha +6 more
doaj +1 more source
Cell Proliferation, Volume 59, Issue 10, October 2026.Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang +9 more
wiley +1 more source
, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914) +2 more
core +1 more source
Glia, Volume 74, Issue 9, September 2026.Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios +7 more
wiley +1 more source
A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes
eLife, 2020 Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx).
Samantha Ebersoll +4 more
doaj +1 more source
Molecules, 2023 Current medication therapy for leishmaniasis and trypanosomiasis remains a major challenge due to its limited efficacy, significant adverse effects, and inaccessibility.
Abdulsalam A. M. Alkhaldi
doaj +1 more source