Results 91 to 100 of about 2,541 (192)

Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-l-cysteine and liquid chromatography with UV detection

, 2009
A bioanalytical method for indirect determination of eflornithine enantiomers in 75 muL human plasma has been developed and validated. l- and d-eflornithine were derivatized with o-phthalaldehyde and N-acetyl-L-cysteine to generate diastereomers which ...
Jansson Löfmark, Rasmus, R\uf6msing, S, Albers, Eva,, Römsing, S,, Römsing, S, Römsing, Susanne,, Jansson L\uf6fmark, Rasmus, Ashton, M.,, Ashton, Michael, Jansson Löfmark, Rasmus,, Albers, E.,, Albers, Eva, Jansson-Löfmark, Rasmus,, Ashton, Michael,, Ashton, M, Jansson-Löfmark, Rasmus, Albers, E, R. Jansson-Löfmark, S. Römsing, E. Albers, M. Ashton   +20 more
core   +1 more source

Eflornithine

Indian Journal of Dermatology, Venereology and Leprology, 2007
Kruti S, Jobanputra, Aruna V, Rajpal, N G, Nagpur   +2 more
openaire   +3 more sources

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

PLoS Neglected Tropical Diseases, 2018
Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially characterised.
James A Thomas, Nicola Baker, Sebastian Hutchinson, Caia Dominicus, Anna Trenaman, Lucy Glover, Sam Alsford, David Horn   +7 more
doaj   +1 more source

Targeting Pharmacological and Nanotechnology Based Therapeutics for Management of Hirsutism: A Comprehensive State-of-the-Art [PDF]

Pharmaceutical Sciences
Hirsutism is characterized by the excessive growth of coarse hair in women, resembling the typical pattern seen in men. It affects between 5 to 10 % of females of reproductive age.
Ishrat Zahoor, Sukhbir Singh, Neelam Sharma, Ikmeet Kaur Grewal, Shahid Nazir Wani   +4 more
doaj   +1 more source

Adjuvant eflornithine to maintain IPL-induced hair reduction in women with facial hirsutism:a randomized controlled trial

, 2016
BACKGROUND: Photoepilation is the treatment of choice for hair removal in patients with hirsutism, but it remains a challenge to prevent regrowth of hairs.OBJECTIVES: The objective of this study was to investigate whether topical eflornithine maintains ...
Haak, C S, Taudorf, E H, Hædersdal, Merete, E.H. Taudorf, Vissing, Anne-Cathrine, C.S. Haak, M. Hædersdal, A.C. Vissing, P.A. Philipsen, Philipsen, P A   +9 more
core   +1 more source

The detection and treatment of human African trypanosomiasis

Research and Reports in Tropical Medicine, 2012
Bernard Bouteille,1 Alain Buguet21Laboratory of Parasitology, Dupuytren University Hospital of Limoges, France; 2Polyclinic Marie-Louise Poto-Djembo, Pointe-Noire, CongoAbstract: Human African trypanosomiasis (HAT) is caused by the injection of ...
Bouteille B, Buguet A
doaj  

The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain

, 2008
Drugs to treat African trypanosomiasis are toxic, expensive and subject to parasite resistance. New drugs are urgently being sought. Although the existing drug, eflornithine, is assumed to reach the brain in high concentrations, little is known about how
Sanderson, Lisa, Dogruel, Murat, Bradley, Barbara, Rodgers, J., Rodgers, Jean, Thomas, Sarah Ann   +5 more
core   +1 more source

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas

, 2018
This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin, Sandra E Ictech, Kenneth R Hess   +2 more
core   +1 more source

Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis

Research and Reports in Tropical Medicine, 2012
Jose R Franco,1 Pere P Simarro,1 Abdoulaye Diarra,2 Jose A Ruiz-Postigo,3 Mireille Samo,1 Jean G Jannin11World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health ...
Franco JR, Simarro PP, Diarra A, Ruiz-Postigo JA, Samo M, Jannin JG   +5 more
doaj  

ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape

Cell Death and Disease
Metabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Han Tao, Xiaojun Wang, Zhiyi Hu, Yiran Li, Mengwen Kong, Yeli Sun, Kun Gao, Xiaoping Wan   +7 more
doaj   +1 more source