Results 21 to 30 of about 1,936 (110)

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

Medical Sciences, 2018
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts   +4 more
doaj   +1 more source

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma brucei gambiense is the main causative agent of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Because of limited alternatives and treatment toxicities, new therapeutic options are urgently needed for patients with HAT.
Frédéric-Antoine Dauchy, Mélanie Bonhivers, Nicolas Landrein, Denis Dacheux, Pierrette Courtois, Florian Lauruol, Sylvie Daulouède, Philippe Vincendeau, Derrick R Robinson   +8 more
doaj   +1 more source

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030

Frontiers in Medicine, 2022
Human African Trypanosomiasis (HAT) is caused by unicellular flagellated protozoan parasites of the genus Trypanosoma brucei. The subspecies T. b. gambiense is mainly responsible for mostly chronic anthroponotic infections in West- and Central Africa ...
Andrés Álvarez-Rodríguez, Andrés Álvarez-Rodríguez, Bo-Kyung Jin, Magdalena Radwanska, Magdalena Radwanska, Stefan Magez, Stefan Magez, Stefan Magez   +7 more
doaj   +1 more source

Potentials of curcumin against polycystic ovary syndrome: Pharmacological insights and therapeutic promises

Heliyon, 2023
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%–20%) when the ovaries create abnormally high levels of androgens, the male sex hormones that are typically present in women in trace amounts.
Tanzina Akter, Md. Sarwar Zahan, Nafisa Nawal, Md. Hasanur Rahman, Tayyabatun Nur Tanjum, Kazi Ifthi Arafat, Akhi Moni, Mohammad Nazrul Islam, Md Jamal Uddin   +8 more
doaj   +1 more source

The development of drugs for treatment of sleeping sickness: a historical review

Parasites & Vectors, 2010
Only four drugs are available for the chemotherapy of human African trypanosomiasis or sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. The history of the development of these drugs is well known and documented. suramin, pentamidine
Steverding Dietmar
doaj   +1 more source

Principles of management of women with hirsutism – a dermatologist’s perspective

Przegląd Dermatologiczny, 2020
Hirsutism is a common clinical diagnosis defined by the presence of excess growth of terminal hair in androgen-sensitive areas. It affects 5–15% of women, often having a significant impact on their daily functioning. Hirsutism is mainly caused by ovarian
Dominik Mikiel, Barbara Olszewska, Adriana Polańska, Zygmunt Adamski, Ryszard Żaba, Aleksandra Dańczak-Pazdrowska   +5 more
doaj   +1 more source

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

PLoS Neglected Tropical Diseases, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Isabel M Vincent, Darren J Creek, Karl Burgess, Debra J Woods, Richard J S Burchmore, Michael P Barrett   +5 more
doaj   +1 more source

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Pharmaceutics, 2023
Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through
Shuruq S. Almuwallad, Dunia A. Alzahrani, Walaa S. Aburayan, Ahmed J. Alfahad, Khulud A. Alsulami, Alhassan H. Aodah, Samar A. Alsudir, Sulaiman S. Alhudaithi, Essam A. Tawfik   +8 more
doaj   +1 more source

Sustainable Multi-Target Drugs for Neglected Tropical Diseases Caused by Trypanosomatids: Dream or Reality?

Proceedings, 2017
The development of nifurtimox-eflornithine combination therapy (NECT) has been a major and emboldening advance towards more effective and simple medications in the field of neglected tropical diseases (NTD) caused by Trypanosomatids. [...]
Maria Laura Bolognesi
doaj   +1 more source

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. [PDF]

PLoS Neglected Tropical Diseases, 2009
BackgroundThe development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T.
Anne J N Kazibwe, Barbara Nerima, Harry P de Koning, Pascal Mäser, Michael P Barrett, Enock Matovu   +5 more
doaj   +1 more source