Results 181 to 190 of about 50,152 (259)

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4836-4854, August 2026.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4592-4609, August 2026.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

A qualitative study examining barriers to buprenorphine for pain management in patients with end stage kidney disease undergoing hemodialysis. [PDF]

J Pain
Edwards KA, Hamm ME, Liebschutz JM, Olejniczak DM, Cavanaugh KL, Wilkie CM, Jhamb M, Bulls HW.   +7 more
europepmc   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Buprenorphine versus full agonist opioids for acute postoperative pain management: an infographic. [PDF]

Reg Anesth Pain Med
Hickey TR, Costa GPA, Avila-Quintero VJ, De Aquino JP.   +3 more
europepmc   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, Volume 38, Issue 8, Page 442-452, August 2026.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Buprenorphine for Children and Adolescents with Sickle Cell Disease: A Scoping Review. [PDF]

Children (Basel)
deBettencourt J, Nagy M, Rotman C, Greco C, Berde C, Archer NM.   +5 more
europepmc   +1 more source

Impact of Antiviral Therapy Scale‐Up Among People Who Inject Drugs in Scotland: Regional Evidence of Hepatitis C Virus Elimination

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background Expansion of highly effective direct‐acting antiviral (DAA) treatment for people who inject drugs (PWID) is regarded as essential to achieve hepatitis C virus (HCV) elimination. A decade since the introduction of DAA treatment, we aimed to assess its roll‐out and associated impact in reducing HCV prevalence among PWID in Scotland ...
Norah E. Palmateer, Pantelis Samartsidis, Christopher Biggam, Andrew McAuley, Scott A. McDonald, John Dillon, Stephen T. Barclay, Samantha J. Shepherd, Rory N. Gunson, Monica Desai, Duncan McCormick, Daniela De Angelis, Matthew Hickman, Sharon J. Hutchinson   +13 more
wiley   +1 more source

Stability Study of Compounded Ethanol-Free Buprenorphine Oral Syringes for the Treatment of Neonatal Opioid Withdrawal Syndrome. [PDF]

J Pediatr Pharmacol Ther
Soni V, Shah SA, Kraft WK, Kaushal G.
europepmc   +1 more source

State Tele-Buprenorphine Prescribing Policies by Medical Professional Type.

JAMA Health Forum
Sousa JL, Landis RK, Senator B, Olalere S, Rigsby J, Minarik L, Levine P, Anderson D, Williams AR, Faherty LJ.   +9 more
europepmc   +1 more source