Results 41 to 50 of about 50,152 (259)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects.

PLoS ONE
Buprenorphine in an extended-release formulation intended for use in laboratory subjects is frequently administered to rats to provide extended analgesia without repeated handling.
Christina M Larson, Cecilia Barajas, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson   +5 more
doaj   +1 more source

Retrospective analysis of heroin detoxification with buprenorphine in a psychiatric hospital in Japan

Neuropsychopharmacology Reports, 2020
Aim We assessed the efficacy of buprenorphine replacement taper therapy in a psychiatric hospital in Japan. Methods Based on the medical records, a retrospective analysis was performed to evaluate the outcomes of buprenorphine replacement taper therapy ...
Tatsushi Nagano, Sohei Kimoto, Katsuro Aso, Takashi Komori, Yasunari Yamaguchi, Kazuya Okamura, Noriya Yamamoto, Toshifumi Kishimoto   +7 more
doaj   +1 more source

Buprenorphine‐naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction Current WHO guidelines recommend using methadone or buprenorphine as maintenance treatments for maternal opioid use disorder. However, buprenorphine‐naloxone, with a lower abuse risk than buprenorphine monotherapy or methadone, offers a ...
Minna M. Kanervo, Sarimari J. Tupola, Eeva M. Nikkola, Krista M. Rantakari, Hanna K. Kahila   +4 more
doaj   +1 more source

Receipt and duration of buprenorphine treatment during pregnancy and postpartum periods in a national privately-insured cohort

Drug and Alcohol Dependence Reports, 2023
Background: Research gaps exist on the use of medications for opioid use disorder (OUD) among birthing people. Methods: This retrospective cohort study included people who underwent childbirth deliveries during 2017-2020 and had a diagnosis of OUD ...
Xi Wang, Zachary Meisel, Katherine Kellom, Jennifer Whitaker, Douglas Strane, Anyun Chatterjee, Rebecka Rosenquist, Meredith Matone   +7 more
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Analysis of energy expenditure and behavioral characteristics in different mouse strains under normal and disease conditions

Animal Models and Experimental Medicine, EarlyView.
Mouse metabolic and behavioral phenotypes are tightly linked to strain, age and disease state, with distinct dysregulation in each disease model, underscoring the need for standardized preclinical experimental conditions. Abstract Background Metabolic and behavioral traits in mice exhibit substantial variability across strains, ages, and disease states,
Jiacheng Zeng, Yuanjun Ji, Yan Zou, Jing Tan, Teng Wu, Conghui Shen, Tongsheng Huang, Shijie Xiong, Mengying Liu, Maoquan Yang, Jingwei Lai, Jiangwei Ma, Junhong Wan, Xinlu Fu, Jiang Qian, Hui Li, Ludong Yuan, Weibin Cai   +17 more
wiley   +1 more source

Treatment setting and buprenorphine discontinuation: an analysis of multi-state insurance claims

Addiction Science & Clinical Practice
Background Potential differences in buprenorphine treatment outcomes across various treatment settings are poorly characterized in multi-state administrative data.
Kevin Y. Xu, Alex K. Gertner, Shelly F. Greenfield, Arthur Robin Williams, Richard A. Grucza   +4 more
doaj   +1 more source

Willingness to receive intravenous buprenorphine treatment in opioid-dependent people refractory to oral opioid maintenance treatment: results from a community-based survey in France

Substance Abuse Treatment, Prevention, and Policy, 2017
Background Injectable opioids are an interesting option for people who inject drugs (PWID) that do not respond to oral Opioid Maintenance Treatment (OMT).
Perrine Roux, Daniela Rojas Castro, Khadim Ndiaye, Laélia Briand Madrid, Virginie Laporte, Marion Mora, Gwenaelle Maradan, Stéphane Morel, Bruno Spire, Patrizia Carrieri   +9 more
doaj   +1 more source