Results 61 to 70 of about 57,075 (302)
Buprenorphine Treatment for Opioid Use Disorder: An Examination of Benefits and Barriers.
The opioid crisis has continued relentlessly throughout the twenty-first century. In order to reduce negative impacts of the opioid crisis, we must increase use of highly effective, FDA-approved medications for opioid use disorder (MOUDs) – including ...
Golan, Olivia K
core +1 more source
Buprenorphine in acute pain: a partial agonist or not? (Letter)
, 2019 Editor—There currently exists confusion regarding the status of buprenorphine as a partial agonist of the μ-opioid receptor (MOP), particularly in the setting of acute pain management for opioid-naïve patients.1 Buprenorphine, a semi-synthetic derivative
White, L +4 more
core +1 more source
Advanced Science, EarlyView.After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng +9 more
wiley +1 more source
Treatment setting and buprenorphine discontinuation: an analysis of multi-state insurance claims
Addiction Science & Clinical PracticeBackground Potential differences in buprenorphine treatment outcomes across various treatment settings are poorly characterized in multi-state administrative data.
Kevin Y. Xu +4 more
doaj +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh +8 more
wiley +1 more source
, 2012 Pharmaceutical maintenance with methadone is the current gold standard for pregnant women with opioid-dependence. While there are many benefits of methadone, its use during pregnancy is associated with high rates of neonatal abstinence syndrome, and long
Whitham, Justine N.
core
Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits
Animal Models and Experimental Medicine, EarlyView.In this study, spinal fusion models in mice, rats and rabbits are compared and discussed. The results show that after comparing the anatomical structure and the complexity of surgical operation, among the three experimental animals in this study, the rabbit as an experimental animal is superior to the mouse and the rat in the establishment of spinal ...
Jianghong Lu, Yicun Hu, Xin Yao
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The French authorities mandated the use of secure prescriptions for pregabalin on May 2021. This study aimed to evaluate the impact of this measure on pregabalin use and misuse in Nouvelle‐Aquitaine, a southwestern French region with around six million inhabitants.
Maika Munech‐Herran +5 more
wiley +1 more source