Results 151 to 160 of about 37,508 (242)

Addiction‐related problems in Japan: A regional perspective

Addiction, Volume 121, Issue 5, Page 1316-1324, May 2026.
Abstract Japan's addiction landscape appears paradoxical. The lifetime use of illicit drugs is among the lowest in Organisation for Economic Cooperation and Development countries, but harm from alcohol, tobacco, and gambling ranks among the world's highest.
Soichiro Ide, Yoko Nishitani, Masahiko Sumitani, Masabumi Minami, Tadashi Isa, Masako Iseki, Michiko Ohkura, Hitoshi Okamoto, Tetsuro Kikuchi, Yuko Sekino, Hidehiko Takahashi, Kenji Takeuchi, Atsumi Nitta, Takeshi Honjo, Hiroshi Matsumoto, Tsuyoshi Miyakawa, Toshiya Murai, Toshihiko Matsumoto, Kazuyuki Nakagome, Kazutaka Ikeda   +19 more
wiley   +1 more source

Clinical benefits and considerations of dextromethorphan and bupropion administered separately for managing depression: A case report. [PDF]

Ment Health Clin
Haghparast P, Olotu B, Yuan C.
europepmc   +1 more source

Sodium‐glucose co‐transporter 2 inhibitors and obesity‐associated cancers in people with type 2 diabetes: A real‐world observational study

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3807-3818, May 2026.
Abstract Aims To investigate the association between sodium‐glucose co‐transporter 2 inhibitors (SGLT‐2i) and obesity‐associated cancers (OAC) in individuals with type 2 diabetes (T2D). Materials and Methods This retrospective cohort study used data from the TriNetX US Collaborative Network.
Testimony Ipaye, Jonathan Goldney, Thomas Yates, Francesco Zaccardi, Kamlesh Khunti, Elina Akalestou, Melanie J. Davies, Karen Brown, Dimitris Papamargaritis   +8 more
wiley   +1 more source

Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms. [PDF]

Drug Alcohol Depend Rep
McKee SA, Lydecker JA, Pittman B, Jastreboff AM, DiLeone RJ, Lavery M, Grilo CM.   +6 more
europepmc   +1 more source

Uptake and early outcomes of a meal replacement intervention in an ethnically diverse adult population living with obesity and significant comorbidity

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3924-3932, May 2026.
Abstract Aims Structured meal replacement low energy diets (MR‐LED) are effective in obesity management, but evidence for individuals of minority ethnic groups or those with BMI >35 kg/m2 and significant comorbidities is limited. Materials and methods We evaluated the early effectiveness of a weight management program delivered by a multidisciplinary ...
James Shand, Naomi Brosnahan, Yannan Jiang, Rinki Murphy   +3 more
wiley   +1 more source

Weight Loss as a Determinant of Histological Improvement in Metabolic Dysfunction‐Associated Steatotic Liver Disease in People With Obesity. A Systematic Review and Network Meta‐Analysis of Randomised Clinical Trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4253-4260, May 2026.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is closely linked to obesity and insulin resistance, and sustained weight loss is associated with histological improvement. Whether different obesity‐management modalities exert weight‐independent hepatic effects remains uncertain.
Matteo Monami, Amanda Belluzzi, Silvio Buscemi, Luca Busetto, Ricardo Cohen, Maurizio De Luca, Andrea Galli, Edoardo Mannucci, Tarissa Z. Petry, Benedetta Ragghianti, Paolo Sbraccia, Dror Dicker   +11 more
wiley   +1 more source

New-Onset Tic Disorder Associated With Bupropion XL: A Rare Case. [PDF]

Cureus
Rashid O, Hooda P, Kaur S.
europepmc   +1 more source

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu, Song Hee Lee, Ji Hyeon Kim, Seung Jin Kim, Hee Eun Kang   +4 more
wiley   +1 more source

DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs. [PDF]

Front Psychiatry
Cheung N.
europepmc   +1 more source

Altered spectral patterns of aperiodic electroencephalography in autism

Psychiatry and Clinical Neurosciences, Volume 80, Issue 5, Page 423-431, May 2026.
Aim The altered ratio of neural excitation (E) and inhibition (I) has been proposed to the etiology of autism spectrum disorder (ASD). Previous studies suggested a lower E/I ratio in autistic individuals compared to non‐autistic comparisons (NACs) in specific brain regions.
Yi‐Ling Chien, Ming Hsien Hsieh, Yi‐Hsuan Hsieh, Yi‐Li Tseng   +3 more
wiley   +1 more source