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Results 121 to 130 of about 3,444,641 (410)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source

Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis

The Lancet Respiratory Medicine, 2019
Summary Background There is a scarcity of published data on the global prevalence of obstructive sleep apnoea, a disorder associated with major neurocognitive and cardiovascular sequelae.
A. Benjafield +14 more
semanticscholar +1 more source

Prelude to 220 or 110

, 1971
[Burden] lay bolted with copper bands to a concrete floor, near two buckets of water in which live 110-volt lines had been submerged. Had anyone visiting the gallery chosen to spill the water, Burden would have been electrocuted.
Burden, Chris
core

A comparison of levels of burden in Indian and White parents with a son or daughter with schizophrenia [PDF]

, 2010
Background: Caregiver burden in mental illness is believed to differ between ethnic groups, but few studies have examined this in schizophrenia in the UK.
Lloyd, H. (Helen) +17 more
core +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source

Shoot

, 1971
Performance took place at F Space, Santa Ana, California. F Space 441 Exposition Blvd. (at Flower) Los Angeles, CA 90007 http://www.usc.edu/dept/finearts/fspace/about.html"At 7:45 p.m. I was shot in the left arm by a friend.
Burden, Chris
core

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Lancet Neurology, 2019
Summary Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial.
C. Johnson +272 more
semanticscholar +1 more source

747

, 1973
"At about 8:00 a.m. at a beach near the Los Angeles International Airport, I fired several shots with a pistol at a Boeing 747."full view, Burden pointing pistol at plane; photograph by Terry ...
Burden, Chris
core

Reflections on the global burden of disease 2010 estimates. [PDF]

, 2013
Peter Byass and colleagues raise questions about the recent, high-profile Global Burden of Disease estimates.
Zaba, B +26 more
core +1 more source

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