Results 251 to 260 of about 2,585,234 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Temporal Trends and Projections of the Burden of Decubitus Ulcers in China: A Cross-Sectional Study Based on the Global Burden of Disease Study 2021. [PDF]

Health Sci Rep
Peng H.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Heatwave and dementia: a systematic analysis for the Global Burden of Disease Study 2019. [PDF]

BMJ Public Health
Chen Y, Luo Y, Yu L, Zheng X, Luo Q.
europepmc   +1 more source

Carga de la esquizofrenia en Centroamérica, 2000–2021: análisis del estudio Global Burden of Disease 2021

Erick Gómez‑Masís, Mariela Barahona‑Villalobos, Juvel Quintanilla‑Gallo, Francisco José Rodríguez‑Fallas   +3 more
openalex   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The Potential of Plant-Based Lifestyle Interventions to Reduce the Burden of Disease in a Multi-Crisis Era. [PDF]

Am J Lifestyle Med
Kolandai K, Wright N, Wilson L, Haitjema H, Wright SR, Foster M, Laking G, Kelaher M, Skaria R, Douglas J, Liew MK, Leighton M, Brunt D, Gold-Smith F, Craig M, Joseph T, Hurlow W, Pittar C, Mortimer S.   +18 more
europepmc   +1 more source

Systemic Sclerosis Burden of Disease

Jennifer Delgadillo
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Global burden of leishmaniasis, 1990-2021: systematic analysis of the global burden of disease study. [PDF]

Int J Equity Health
Li S, Qiu T, Zhao N, Liu M, He X, Wang X, Jiang S, Luo M, Wang S, Zhang L, Wang X.   +10 more
europepmc   +1 more source