Results 231 to 240 of about 2,585,234 (304)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Unequal patterns of tuberculosis in women of reproductive age: Insights from the Global burden of disease study 2021. [PDF]

Infect Med (Beijing)
Liu T, Zhang L, Liu J, Liu Y, Xiong A, Ran Q, He X, Jiang L, Li G, Wang J.   +9 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

RISING INCIDENCE, MORTALITY, AND DISABILITY-ADJUSTED LIFE YEARS OF INFLAMMATORY BOWEL DISEASE IN THE UNITED STATES: A SYSTEMIC ANALYSIS OF THE GLOBAL BURDEN OF DISEASE STUDY [PDF]

Chun‐Wei Pan, Bashar M. Attar, Alejandro Nieto-Dominguez   +2 more
openalex   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The global burden of disease attributable to suboptimal fruit and vegetable intake, 1990-2021: a systematic analysis of the global burden of disease study. [PDF]

BMC Med
Xu X, Yan P, Chen W, Wei W, Thomson B, Ruan S, Cao Z, Ou C, Geldsetzer P, Han T, Wang J, Chen S, Li J.   +12 more
europepmc   +1 more source

P2 Economic Burden and Healthcare Resource Utilization in Sjögren's Disease: A Systematic Literature Review [PDF]

Jae Woo Choi, Anthony Christodoulou, Antoine G. Sreih, Katharina Höfer, Mir‐Masoud Pourrahmat, Mir Sohail Fazeli, Benjamin A. Fisher   +6 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Burden of pancreatic cancer in Iran: an analysis of Global Burden of Disease 2021. [PDF]

Gastroenterol Hepatol Bed Bench
Azizmohammad Looha M, Saberi Shahrbabaki A, Zamani M, Zareie Shab Khaneh A, Javadi S, Sadeghloo Z, Mohammadpoor A, Sharifi Z, Bahadorimonfared A, Gholami Shahrebabak M, Rostami-Nejad M.   +10 more
europepmc   +1 more source