Results 41 to 50 of about 167,604,375 (245)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Who has the burden of proof? [PDF]
Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философияThis text responds to A.Z. Chernyak's reflections on the problem of proving God's existence, which in turn were inspired by the publication of the collection "The Existence of God? Modern Positions and Approaches" (2025), edited by E.V. Loginov. I accept
Vladimir Shokhin
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The Burden of Proof and Evidence-Based Reasoning in the Decisions of the Administrative Court of Justice [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒UmūmīIntroduction The admission of evidence and the burden of proving a claim are crucial elements in asserting rights in any legal proceeding, including the administrative proceeding.
Ali Mashhadi, Hormoz Yazdani Zunuz
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Burden of disease scenarios by state in the USA, 2022-50: a forecasting analysis for the Global Burden of Disease Study 2021. [PDF]
BACKGROUND: The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and
GBD 2021 US Burden of Disease and Forecasting Collaborators, +1 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Sharing of the burden of proof in cases on racial discrimination before the ECtHR
, 2021 Kristin Henrard- "Sharing of the burden of proof in cases on racial discrimination before the ECtHR: a mixed account".Webinar "Evidence and Proof in Proceedings before the European Court of Human Rights" organized by DISSECT (http://dissect.ugent.be).5 ...
Dembour, Marie-BenedicteeditorRE220001916715928020031827470000-0002-3270-4067ea0aef39-e5d3-11e9-b023-989f36433135 +2 more
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