Results 51 to 60 of about 2,588 (258)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Вестник Кемеровского государственного университета, 2015 The paper deals with the issue of child burial grounds of the Bronze Age on theterritoryofWestern Siberia. It contains the results of quantitative and qualitative analyses of the burial mounds goods, a specific set of attributes and values associated ...
O. V. Umerenkova
doaj
Българско е-Списание за Археология, 2020 This study examines the use of anthropomorphic figurines in burial practices of the Late Eneolithic Varna, KGKVI and KSB cultures. It contains the presentation and analysis of data on their deposition in necropolises, which show that they occurred ...
Vanya Stavreva
doaj
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Grób kultury ceramiki sznurowej ze stanowiska 10 w Wilczycach, pow. sandomierski
Przegląd Archeologiczny, 2017 The authors of the paper present the results of research, the subject of which was the inhumation burial of the Corded Ware culture from Wilczyce. The site is located on the culmination of the southern slope of a loess hill, rising directly above the ...
Piotr Włodarczak +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
“Frozen” Pazyryk Burial Without Grave Goods on the Ukok Plateau
Problems of Archaeology, Ethnography, Anthropology of Siberia and Neighboring TerritoriesThe burial of a woman in mound No. 2 at the Verkh-Kaldzhin 2 Pazyryk burial ground was studied by V.I. Molodin in 1995. It had not been disturbed by robbers and was in the ice lens at the time of the excavations. However, unlike two other burials from mounds No. 1 and 3, little is known about it.
N.V. Polosmak +2 more
openaire +1 more source
Поволжская археологияThe article deals with the new materials in the form of archaeological complexes, obtained during excavations of catacomb burial structures of the Kultobe burial ground of the I–IV centuries in the Southern Kazakhstan, which in historical, ethnic ...
Podushkin Alexander N.
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source