Results 61 to 70 of about 135,194 (308)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Cultural Components of the Ust-Vetluga Burial Ground

open access: yesПоволжская археология, 2013
The cultural components of the Ust-Vetluga burial ground site, which is located on the left bank of the Cheboksary water reservoir, near Yurino village, the Mari El Republic, are analyzed in the article.
Soloviev Boris S.
doaj   +1 more source

Women Traders of the Viking Age: An Analysis of Grave Goods [PDF]

open access: yes, 2017
The image of Viking culture that most of us carry in our heads is largely masculine and testosterone-driven. Where are women in the Scandinavian past? Examining grave goods associated with female burials—including items of personal adornment—this article
Mierswa, Emily
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

The excavation of Non Ban Jak, Northeast Thailand - A report on the first three seasons [PDF]

open access: yes, 2014
Non Ban Jak is a large, moated site located in the upper Mun Valley, Northeast Thailand. Excavations over three seasons in 2011-4 have revealed a sequence of occupation that covers the final stage of the local Iron Age.
Cameron, Judith   +7 more
core   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Tumuli preistorici cercetaţi în anul 2024 în localitatea Păuleşti (jud. Prahova)

open access: yesMateriale și Cercetări Arheologice
In 2024, three prehistoric burial mounds were excavated in Păulești, uncovering four inhumation graves : three adult males and one subadult. Only the subadult grave contained grave goods — two silver hair rings.
Frînculeasa, A., Negrea, O., Ghinea, E.
doaj   +1 more source

Third Century AD Burial Vaults from the Cemetery of Opushki

open access: yesНижневолжский археологический вестник
There was some important event taking place in the Crimea in the third century AD or a little bit earlier that was probably reflected by the appearance of burial vaults of a special design that had not been previously known in Crimea.
Igor N. Khrapunov
doaj   +1 more source

The Early-Sarmatian Burial in the East Crimea

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2018
The paper presents the materials of investigation of the burial that has been discovered in 2016 under a monumental stone construction / passway through a ditch in front of the Uzunlar bank, conditionally named ‘Bosporus Gate’.
Viktor V. Kropotov
doaj   +1 more source

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