Glycoproteomic and proteomic analysis of Burkholderia cenocepacia reveals glycosylation events within FliF and MotB are dispensable for motility [PDF]
Microbiology SpectrumAcross the Burkholderia genus O-linked protein glycosylation is highly conserved. While the inhibition of glycosylation has been shown to be detrimental for virulence in Burkholderia cepacia complex species, such as Burkholderia cenocepacia, little is ...
Jessica M. Lewis +4 more
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Oridonin Attenuates Burkholderia cenocepacia Virulence by Suppressing Quorum-Sensing Signaling [PDF]
Microbiology Spectrum, 2022 Burkholderia cenocepacia is a human opportunistic pathogen that mostly employs two types of quorum-sensing (QS) systems to regulate its various biological functions and pathogenicity: the cis-2-dodecenoic acid (BDSF) system and the N-acyl homoserine ...
Xia Li +6 more
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Phage-antibiotic synergy reduces Burkholderia cenocepacia population [PDF]
BMC Microbiology, 2023 Background Burkholderia cenocepacia is an opportunistic pathogen that can cause acute and chronic infections in patients with weakened immune systems and in patients with cystic fibrosis. B.
Anna G. Mankovich +5 more
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The Small RNA NcS25 Regulates Biological Amine-Transporting Outer Membrane Porin BCAL3473 in Burkholderia cenocepacia [PDF]
mSphere, 2023 Regulation of porin expression in bacteria is complex and often involves small-RNA regulators. Several small-RNA regulators have been described for Burkholderia cenocepacia, and this study aimed to characterize the biological role of the conserved small ...
Andrea M. Sass, Tom Coenye
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Surface Motility Favors Codependent Interaction between Pseudomonas aeruginosa and Burkholderia cenocepacia [PDF]
mSphere, 2022 Interactions between different bacterial species shape bacterial communities and their environments. The opportunistic pathogens Pseudomonas aeruginosa and Burkholderia cenocepacia both can colonize the lungs of individuals affected by cystic fibrosis ...
Charles Morin +3 more
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Insights into the diverse roles of the terminal oxidases in Burkholderia cenocepacia H111. [PDF]
Sci RepBurkholderia cenocepacia H111 is an obligate aerobic bacterium which has been isolated from a cystic fibrosis (CF) patient. In CF lungs the environment is considered micro-oxic or even oxygen-depleted due to bacterial activities and limited oxygen ...
Paszti S +6 more
europepmc +2 more sources
Bacteriophage steering of Burkholderia cenocepacia toward reduced virulence and increased antibiotic sensitivity. [PDF]
J Bacteriol, 2023 Antibiotic resistance in bacteria is a growing global concern and has spurred increasing efforts to find alternative therapeutics, such as the use of bacterial viruses, or bacteriophages.
Ruest MK, Supina BSI, Dennis JJ.
europepmc +2 more sources
The risk of contaminated ultrasound gels in the intensive care unit: lessons from an outbreak of <i>Burkholderia cenocepacia</i>. [PDF]
Antimicrob Steward Healthc EpidemiolBackground: Burkholderia cenocepacia is an environmental Gram-negative bacterium, resistant to many antibiotics and antiseptics, that can survive in aqueous hospital environments. We investigated an outbreak of B.
Ahamed Sha B +12 more
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Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice. [PDF]
NPJ VaccinesBurkholderia cenocepacia causes life-threatening infections in immunocompromised patients. Treatment is challenging due to intrinsic antibiotic multiresistance, so vaccination provides an alternative approach.
Gawad WE +4 more
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Acidic pH modulates <i>Burkholderia cenocepacia</i> antimicrobial susceptibility in the cystic fibrosis nutritional environment. [PDF]
Microbiol Spectr, 2023 Burkholderia cenocepacia is an opportunistic pathogen correlated with increased disease severity and mortality in cystic fibrosis (CF) patients.
Morales LD, Av-Gay Y, Murphy MEP.
europepmc +2 more sources