Results 111 to 120 of about 6,089 (200)

Burkholderia cepacia, cystic fibrosis and outcomes following lung transplantation: experiences from a single center in Brazil

Clinics, 2018
OBJECTIVES: To evaluate the impact of Burkholderia cepacia complex colonization in cystic fibrosis patients undergoing lung transplantation. METHODS: We prospectively analyzed clinical data and respiratory tract samples (sputum and bronchoalveolar ...
Danila de Souza Carraro, Rafael Medeiros Carraro, Silvia Vidal Campos, Leandro Ryuchi Iuamoto, Karina Andrighetti de Oliveira Braga, Lea Campos de Oliveira, Ester Cerdeira Sabino, Flavia Rossi, Paulo Manuel Pêgo-Fernandes   +8 more
doaj   +1 more source

The Changing Transplant Landscape in the Era of Elexacaftor/Tezacaftor/Ivacaftor: A Word of Caution

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background Elexacaftor/tezacaftor/ivacaftor (ETI) has dramatically changed the landscape of cystic fibrosis (CF) care, including in those who require lung transplantation. The objectives of the study were to describe the cohort demographics and outcomes of primary lung transplant recipients before and after the availability of ETI.
Julie Semenchuk, Eliza Tuff‐Gordon, Xiayi Ma, Jenna Sykes, Stephanie Y. Cheng, Meghan Aversa, Cecilia Chaparro, Elizabeth Tullis, Anne L. Stephenson   +8 more
wiley   +1 more source

Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia

, 2007
Burkholderia cenocepacia is a gram-negative, non-spore-forming bacillus and a member of the Burkholderia cepacia complex. B. cenocepacia can survive intracellularly in phagocytic cells and can produce at least one superoxide dismutase (SOD).
M. A. Valvano, K. E. Keith, Keith, Karen E, Valvano, Miguel A; id_orcid   +3 more
core   +1 more source

Genetic Determinants Associated With in Vivo Survival of Burkholderia cenocepacia in the Caenorhabditis elegans Model

Frontiers in Microbiology, 2018
A Burkholderia cenocepacia infection usually leads to reduced survival and fatal cepacia syndrome in cystic fibrosis patients. The identification of B. cenocepacia essential genes for in vivo survival is key to designing new anti-infectives therapies. We
Yee-Chin Wong, Moataz Abd El Ghany, Moataz Abd El Ghany, Raeece N. M. Ghazzali, Soon-Joo Yap, Chee-Choong Hoh, Arnab Pain, Sheila Nathan   +7 more
doaj   +1 more source

Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients

, 2004
In Belgian cystic fibrosis (CF) clinics, sputum samples are evaluated on selective MAST medium routinely every 3 months. In this study, in 1993 and 1999, isolates were further examined by recA restriction fragment length polymorphism analysis and pulsed ...
De Boeck, K, Doherty, C, Lebecque, Patrick, Govan, J R W, Laevens, S, Van Schil, L, Vandamme, P, Malfroot, A, Knoop, C, the Belgian Burkholderia cepacia study group   +9 more
core   +1 more source

Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient

Frontiers in Microbiology, 2017
Burkholderia cenocepacia is an opportunistic pathogen associated with chronic lung infections and increased risk of death in patients with cystic fibrosis (CF).
A.A. Hassan, Rita F. Maldonado, Sandra C. dos Santos, Flaviana Di Lorenzo, Alba Silipo, Carla P. Coutinho, Vaughn S. Cooper, Antonio Molinaro, Miguel A. Valvano, Isabel Sá-Correia   +9 more
doaj   +1 more source

Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia

BioMetals, 2015
Burkholderia cenocepacia is a bacterial pathogen which causes severe respiratory infections in cystic fibrosis (CF). These studies were aimed at gaining an insight into the iron acquisition strategies of B. cenocepacia. In iron restricted conditions, genes associated with the synthesis and utilisation of ornibactin (pvdA, orbA, orb F) were ...
Tyrrell, J., Whelan, N., Wright, C., Sa-Correia, I., McClean, S., Thomas, M., Callaghan, M.   +6 more
openaire   +3 more sources

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

mSphere, 2019
O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-GalNAc-(1,3)-β-GalNAc to membrane exported proteins in Burkholderia cenocepacia is required for bacterial fitness and ...
Cameron C. Oppy, Leila Jebeli, Miku Kuba, Clare V. Oates, Richard Strugnell, Laura E. Edgington-Mitchell, Miguel A. Valvano, Elizabeth L. Hartland, Hayley J. Newton, Nichollas E. Scott   +9 more
doaj   +1 more source

Identification of the essential genome of Burkholderia cenocepacia K56-2 to uncover novel antibacterial targets

, 2016
Burkholderia cenocepacia K56-2 is a clinical isolate of the Burkholderia cepacia complex, a group of intrinsically antibiotic resistant opportunistic pathogens, for which few treatment options are available.
Gislason, April Shelley
core   +1 more source

Comparative Genomics Identified PenR E151V Substitution Associated with Carbapenem-Resistance Burkholderia cepacia Complex and a Novel Burkholderia cepacia Complex Specific OXA-1043 Subgroup

Infection and Drug Resistance, 2023
Ya-Chun Liao,1 Yao-Ting Huang,2,* Chien-Hao Tseng,1 Chia-Wei Liu,1 Po-Yu Liu1,3,4,* 1Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Department of Computer Science and ...
Liao YC, Huang YT, Tseng CH, Liu CW, Liu PY   +4 more
doaj