Results 121 to 130 of about 29,723 (221)

The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection

mBio, 2021
B. cenocepacia is often considered the most virulent species in the Bcc because of its close association with cepacia syndrome in addition to its capacity to cause chronic lung infections in CF patients (1).
N. Loeven, Andrew I Perault, P. Cotter, C. Hodges, J. Schwartzman, T. Hampton, J. Bliska   +6 more
semanticscholar   +1 more source

Zebrafish as a Versatile Model Organism: From Tanks to Treatment

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava, Kalyani Eswar, Sasvat Sayee Ram Ramesh, Akshit Prajapati, Tanvi Sonpipare, Apoorva Basa, Mounika Gubige, Sribala Ponnapalli, Shashidhar Thatikonda, Aravind Kumar Rengan   +9 more
wiley   +1 more source

Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia

Frontiers in Microbiology, 2019
Burkholderia cenocepacia H111 is an opportunistic pathogen associated with chronic lung infections in cystic fibrosis patients. Biofilm formation, motility and virulence of B.
Anja M. Richter, Mustafa Fazli, Nadine Schmid, Rebecca Shilling, Angela Suppiger, Michael Givskov, Michael Givskov, Leo Eberl, Tim Tolker-Nielsen   +8 more
doaj   +1 more source

Chimerolectins: Classification, structural architecture, and functional perspectives

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Vanir Reis Pinto‐Junior, Benildo Sousa Cavada, Kyria Santiago Nascimento   +2 more
wiley   +1 more source

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein. [PDF]

PLoS ONE, 2013
Cystic fibrosis (CF) is the most common lethal inherited genetic disorder affection Caucasians. Even with medical advances, CF is life-shortening with patients typically surviving only to age 38.
Laura A Novotny, Amal O Amer, M Elizabeth Brockson, Steven D Goodman, Lauren O Bakaletz   +4 more
doaj   +1 more source

A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability [PDF]

, 2014
The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not yet been characterized. However, the B. cenocepacia genome contains homologs of genes encoding PG biosynthetic functions in other bacteria.
Mohamed, Yasmine Fathy, Valvano, Miguel A   +1 more
core   +1 more source

Functional relocation of the maize chloroplast atpB gene to the nucleus restores photosynthetic competence to a gene‐edited non‐photosynthetic mutant

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3510-3523, September 2025.
Summary With the increasing food demands of a global population projected to reach 9.6 billion by 2050, there is an urgent need to increase crop productivity. Bioengineering approaches to boost crop yields include enhancing photosynthetic capacity, though relatively few efforts focus on C4 crop species despite their significant presence in agriculture.
Venkata RamanaRao Mangu, Kelsey Jenkins, Anna Pratt, Kara A. Boltz, Leila Pazouki, Alice Y. Hui, Muruganantham Mookkan, Jeffrey M. Staub   +7 more
wiley   +1 more source

Macrophages as drivers of an opportunistic infection

Microbial Cell, 2017
Opportunistic pathogens are a worldwide cause of mortality and morbidity, and infections with intrinsically antibiotic-resistant pathogens have a large clinical, social and economic impact.
Annette C. Vergunst, Nazareth Lopez Carranza, Lili Zhang, Margarida C. Gomes, Yara Tasrini, Annemarie H. Meijer, David O’Callaghan   +6 more
doaj   +1 more source

Cystic Fibrosis Year in Review 2024

Pediatric Pulmonology, Volume 60, Issue 8, August 2025.
ABSTRACT In 2024, important advances for people with cystic fibrosis (CF) were published. Important guidelines for newborn screening and care of infants diagnosed with CF transmembrane conductance regulator (CFTR)‐Related Metabolic Syndrome/Cystic Fibrosis Screen Positive Inconclusive Diagnosis (CRMS/CFSPID) were published alongside related key lessons
Adrienne P. Savant
wiley   +1 more source

The Effect of 2-Thiocyanatopyridine Derivative 11026103 on Burkholderia Cenocepacia: Resistance Mechanisms and Systemic Impact

Antibiotics, 2019
Bacteria of the Burkholderia cepacia complex (Bcc) are associated with significant decline of lung functions in cystic fibrosis patients. Bcc infections are virtually impossible to eradicate due to their irresponsiveness to antibiotics.
Jaroslav Nunvar, Andrew M. Hogan, Silvia Buroni, Svetlana Savina, Vadim Makarov, Silvia T. Cardona, Pavel Drevinek   +6 more
doaj   +1 more source