Results 141 to 150 of about 4,698 (167)

Isolation ofBurkholderia cenocepaciaandBurkholderia vietnamiensisfrom human sewage

International Journal of Environmental Health Research, 2009
Fresh human sewage was examined from a sewage treatment plant for the presence of members of the Burkholderia cepacia complex (BCC) of bacterial organisms and confirmed the presence of viable B. cenocepacia and B. vietnamiensis, by a combination of cultural, phenotypic and genotypic techniques.
McNeely, Damian, Moore, John E., Elborn, J. Stuart, Millar, B. Cherie, Rendall, Jackie, Dooley, James S.G   +5 more
openaire   +3 more sources

Expression and Characterization of Penicillin-Binding Proteins in Burkholderia cenocepacia

Current Microbiology, 2009
Putative penicillin-binding proteins (PBPs) were identified in the genome of the Burkholderia cenocepacia strain J2315 based on homology to E. coli PBPs. The three sequences identified as homologs of E. coli PBP1a, BCAL2021, BCAL0274, and BCAM2632, were cloned and expressed as His(6)-tagged fusion proteins in E. coli.
Kimberly Musa, Specht, Kyle H, Sheetz, Courtney M, Alexander, Lilian T, Lamech, Lauren H, O'Connor, Dawn M, Walker, Hilary P, Stevenson   +6 more
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Vaccines to Overcome Antibiotic Resistance: The Challenge of Burkholderia cenocepacia

Trends in Microbiology, 2020
Cystic fibrosis (CF) patients are at particular risk of infection by microorganisms that are resistant to several antibiotics. About 3% of CF patients are colonized by Burkholderia cenocepacia, and this represents a major threat because of its intrinsic high level of drug resistance and the lack of a safe and effective treatment protocol.
SCOFFONE VIOLA, Barbieri G., Buroni S., Scarselli M., Pizza M., Rappuoli R., Riccardi G.   +6 more
openaire   +3 more sources

Identification of Sodium Chloride-Regulated Genes in Burkholderia cenocepacia

Current Microbiology, 2008
Previous studies have suggested that the airways of cystic fibrosis (CF) patients have elevated sodium chloride (NaCl) levels due to the malfunctioning of the CF transmembrane conductance regulator protein. For bacteria to survive in this high-salt environment, they must adjust by altering the regulation of gene expression. Among the different bacteria
Shantanu, Bhatt, Christine L, Weingart
openaire   +2 more sources

Burkholderia cenocepacia Lipopolysaccharide, Lipid A, and Proinflammatory Activity

American Journal of Respiratory and Critical Care Medicine, 2004
Abstract Organisms from the Burkholderia cepacia complex are important pathogens in cystic fibrosis and are associated with increased rates of sepsis and death. These organisms comprise nine closely related species known as genomovars. B. cenocepacia (genomovar III) is the most prevalent and appears the most virulent.
De Soyza A, Ellis CD, Khan CMA, Corris P, Demarco de Hormaeche R   +4 more
openaire   +3 more sources

Characterization of a Novel Two-Component System in Burkholderia cenocepacia

Current Microbiology, 2014
Two-component systems are important regulatory systems that allow bacteria to adjust to environmental conditions, and in some bacteria are used in pathogenesis. We identified a novel two-component system in Burkholderia cenocepacia, an opportunistic pathogen that causes pneumonia in cystic fibrosis (CF) patients.
Callie R, Merry, Michael, Perkins, Lin, Mu, Bridget K, Peterson, Rebecca W, Knackstedt, Christine L, Weingart   +5 more
openaire   +2 more sources

Bovine lactoferrin interacts with cable pili of Burkholderia cenocepacia

BioMetals, 2010
In this study we evaluated the ability of lactoferrin, the most abundant antimicrobial protein in airway secretions, to bind the surface structures of a Burkholderia strain cystic fibrosis-isolated. Burkholderia cenocepacia is a gram-negative bacterium involved as respiratory pathogen in cystic fibrosis patient infections.
Maria Grazia Ammendolia, Lucia Bertuccini, Francesca Iosi, Fabio Minelli, BERLUTTI, Francesca, VALENTI, PIERA, Fabiana Superti   +6 more
openaire   +3 more sources

Differential persistence of Burkholderia multivorans and Burkholderia cenocepacia in the mouse

2009
Members of the Burkholderia cepacia complex (BCC) of organisms are important opportunistic pathogens, particularly in cystic fibrosis (CF) patients. Infection with members of the BCC is associated with poor prognosis. There is speculation that the BCC are intracellular pathogens, surviving and growing inside epithelial cells or professional phagocytes.
openaire   +1 more source

An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients

Infection, 2010
Burkholderia cepacia is a common environmental bacterium that is resistant to disinfectants, and therefore is often encountered as a hospital-acquired pathogen. We describe an outbreak of B. cenocepacia bacteremia among hospitalized oncology patients.A matched case-control study and an extensive environmental investigation were conducted.
T, Mann, D, Ben-David, A, Zlotkin, D, Shachar, N, Keller, A, Toren, A, Nagler, G, Smollan, A, Barzilai, G, Rahav   +9 more
openaire   +2 more sources

Antimicrobial Properties of an Oxidizer Produced by Burkholderia cenocepacia P525

Current Microbiology, 2014
A compound with both oxidizing properties and antibiotic properties was extracted and purified from broth cultures of Burkholderia cenocepacia strain P525. A four step purification procedure was used to increase its specific activity ~400-fold and to yield a HPLC-UV chromatogram containing a single major peak.
William J, Hunter, Dan K, Manter
openaire   +2 more sources