Phage therapy to treat cystic fibrosis Burkholderia cepacia complex lung infections: perspectives and challenges [PDF]
Frontiers in MicrobiologyBurkholderia cepacia complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortality.
Jack S. Canning +11 more
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Exploring phage–host interactions in Burkholderia cepacia complex bacterium to reveal host factors and phage resistance genes using CRISPRi functional genomics and transcriptomics [PDF]
Microbiology SpectrumComplex interactions of bacteriophages with their bacterial hosts determine phage host range and infectivity. While phage defense systems and host factors have been identified in model bacteria, they remain challenging to predict in non-model bacteria ...
Ben Diaz +3 more
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Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure [PDF]
, 2017 The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection.
Peeters, Charlotte +5 more
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Spondylodiscitis caused by the Burkholderia cepacia complex [PDF]
Revista da Sociedade Brasileira de Medicina TropicalRulian Christi Souza Rodrigues Candido +4 more
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Microbiology Spectrum, 2021 The Burkholderia cepacia complex (Bcc) comprises several species of closely related, versatile bacteria. Some Bcc strains produce 4-hydroxy-3-methyl-2-alkylquinolines (HMAQs), analogous to the 4-hydroxy-2-alkylquinolines of Pseudomonas aeruginosa.
Pauline M. L. Coulon +2 more
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Iron metabolism in bacterial cells: from physiological significance to a new class of antimicrobial agents [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2022 Infectious complications in the respiratory tract caused by microorganisms from the Burkholderia cepacia complex are the main cause of death among patients with cystic fibrosis.
Kozlov A.V. +4 more
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Community Acquired Burkholderia cepacia Bacteraemia Presenting as MODS in an Immunocompetent Individual: An Unusual Case [PDF]
Journal of Clinical and Diagnostic Research, 2017 Burkholderia cepacia has been recognized as a group of highly virulent organisms known as Burkholderia cepacia complex (Bcc). Bcc are ubiquitous in nature and most commonly found in moist environment, on plant roots and soil.
Ritesh Ranjan +2 more
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Burkholderia Infections in Diabetic Section Patients Emerging as a Challenge for Physicians: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2019 The genus Burkholderia comprises more than 40 species. Medically important members of this genus are Burkholderia cepacia (B.cepacia), Burkholderia pseudomallei (B.pseudomallei) and Burkholderia mallei (B.mallei).
SHUBHRANSU PATRO +3 more
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Burkholderia cepacia Complex Lumbar Spondylodiscitis: A Rare Nosocomial Infection
Case Reports in Infectious Diseases, 2022 Pyogenic spondylodiscitis is rarely caused by Burkholderia cepacia complex. B. cepacia is widespread in the environment and recognized as an opportunistic pathogen for patients with cystic fibrosis and immune disorders.
Rachel Subramanian, Lynn Fitzgibbons
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PLoS Neglected Tropical Diseases, 2021 BackgroundBurkholderia sensu stricto is comprised mainly of opportunistic pathogens. This group is widely distributed in the environment but is especially important in clinical settings.
Georgina Meza-Radilla +4 more
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