Results 81 to 90 of about 9,592 (219)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Right lung agenesis with multi-drug-resistant Cepacia syndrome: A case report

Journal of Family Medicine and Primary Care
Lung agenesis (LA) is a rare congenital anomaly that refers to an absence of lung tissue and bronchi. Burkholderia cepacia complex (BCC) causes a fatal acute necrotising pneumonia called Cepacia syndrome.
Mohit Kondisetti, Priyavardhan Mishra, Anant Patil, Nikhil Sarangdhar, Sankeerth Chanamolu   +4 more
doaj   +1 more source

Function and Structure Relationships With Inflammation Differ in Two Chronic Suppurative Lung Diseases

Pediatric Pulmonology, Volume 61, Issue 5, May 2026.
ABSTRACT Rationale Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are characterized by neutrophilic airway inflammation but differ in clinical features. Objectives We investigated relationships of pulmonary and systemic inflammatory markers with functional and structural lung disease.
Teresa Fuchs, Jacqueline Donovan, Andrew Ives, Samantha Irving, Gwyneth Davies, Claire Hogg, Eric Alton, Gemma Wilson, Andrew Bush, Jane C. Davies   +9 more
wiley   +1 more source

Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients

BMC Pulmonary Medicine, 2018
Background Infection with Burkholderia cepacia complex (Bcc) results in a heterogeneous clinical course ranging from asymptomatic colonization of the airways to fulminant respiratory failure in patients with cystic fibrosis (CF).
Bryan A. Garcia, Jacque L. Carden, Dana L. Goodwin, Tim A. Smith, Amit Gaggar, Kevin Leon, Veena B. Antony, Steven M. Rowe, George M. Solomon   +8 more
doaj   +1 more source

Follow‐Up of Children With Primary Ciliary Dyskinesia

Pediatric Pulmonology, Volume 61, Issue 5, May 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder resulting in defective ciliary motility, which leads to a spectrum of clinical manifestations, including chronic upper and lower respiratory infections, middle ear disease, situs abnormalities, congenital heart defects, and infertility.
Bruna Rubbo, Jonathan Wen Yi Ong, William Tsang, Lydia M. Newman, Jane S. Lucas   +4 more
wiley   +1 more source

Species Abundance and Diversity of Burkholderia cepacia Complex in the Environment [PDF]

Applied and Environmental Microbiology, 2005
ABSTRACT Despite considerable interest in studying Burkholderia cepacia complex in the environment, we still do not have efficient methods to detect, isolate, and screen large numbers of B. cepacia isolates. To better describe the ecology and diversity of B. cepacia
Alban, Ramette, John J, LiPuma, James M, Tiedje   +2 more
openaire   +2 more sources

Burkholderia vietnamiensis Bacteraemia After Lung Transplantation in a Patient With Diffuse Panbronchiolitis

Respirology Case Reports, Volume 14, Issue 5, May 2026.
Persistent Burkholderia cepacia complex bacteraemia occurred after lung transplantation for diffuse panbronchiolitis. Despite apparent in vitro susceptibility to meropenem, bacteraemia persisted and antimicrobial therapy was modified. This case highlights the importance of integrating clinical evolution with antimicrobial susceptibility testing when ...
Taiki Ryo, Ken‐ichi Iwata, Toyofumi Fengshi Chen‐Yoshikawa   +2 more
wiley   +1 more source

Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Yahya Kanani, Ahmad Oryan, Abdollah Derakhshandeh   +2 more
wiley   +1 more source

Distinguishing Species of the Burkholderia cepacia Complex and Burkholderia gladioli by Automated Ribotyping [PDF]

Journal of Clinical Microbiology, 2000
ABSTRACT Several species belonging to the genus Burkholderia are clinically relevant, opportunistic pathogens that inhabit major environmental reservoirs. Consequently, the availability of means for adequate identification and epidemiological characterization of individual environmental or clinical ...
Brisse, S, Verduin, CM, Milatovic, D, Fluit, A, Verhoef, J, Laevens, S, Vandamme, P, Tümmler, B, Verbrugh, Henri, Belkum, Alex   +9 more
openaire   +3 more sources

Burkholderia cepacia complex infections beyond hospital outbreaks: A 22-Year analysis of clinical characteristics, antimicrobial resistance, and mortality predictors

Journal of Infection and Public Health
Background: Burkholderia cepacia complex bacteria are intrinsically multidrug-resistant opportunistic pathogens that pose a growing threat in hospital settings, particularly among immunocompromised patients.
Marwan Jabr Alwazzeh, Amani Alnimr, Sara M. Alwarthan, Mashael Alhajri, Jumanah Algazaq, Bashayer M. AlShehail, Basel A. Darweesh, Mohammed A. Basheikh, Reem S. AlSulaiman, Saud A. Alamro, Jawad ur Rahman, Mohammad T. Al-Hariri   +11 more
doaj   +1 more source