Results 61 to 70 of about 22,717 (216)

A multi-country study using MALDI-TOF mass spectrometry for rapid identification of Burkholderia pseudomallei

BMC Microbiology, 2021
Background Burkholderia pseudomallei is the bacterial causative agent of melioidosis, a difficult disease to diagnose clinically with high mortality if not appropriately treated. Definitive diagnosis requires isolation and identification of the organism.
Wanitda Watthanaworawit, Tamalee Roberts, Jill Hopkins, Ian Gassiep, Robert Norton, Matthew T. Robinson, Joy Silisouk, Poda Sar, Sena Sao, Premjit Amornchai, Direk Limmathurotsakul, Vanaporn Wuthiekanun, Francois Nosten, Andrew J. H. Simpson, Paul Turner, Clare L. Ling   +15 more
doaj   +1 more source

Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]

, 2013
The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core  

Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity [PDF]

, 2016
This study was funded by the National Health and Medical Research Council via awards 1046812 and 1098337, and the Wellcome Trust Sanger Institute via award 098051. S.J.P.
Buller, Nicky, Chapple, Stephanie N. J., Currie, Bart J, Golledge, Clayton, Holden, Matthew T. G., Mayo, Mark, Peacock, Sharon J., Price, Erin P., Sarovich, Derek S.   +8 more
core   +1 more source

Double‐Duty Drugs: Repositioning Antipsychotics to Combat Bacterial Infections

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Antipsychotics can exert antibacterial effects via several mechanisms: (1, 2) Due to their amphiphilic and cationic characteristics, antipsychotics can negatively affect the integrity of the plasma membrane by disrupting its structure and electrochemical potential.
Navid Faraji, Mohammad Abavisani, Negar Ebadpour, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Burkholderia pseudomallei in Soil, US Virgin Islands, 2019

Emerging Infectious Diseases, 2020
The distribution of Burkholderia pseudomallei in the Caribbean is poorly understood. We isolated B. pseudomallei from US Virgin Islands soil. The soil isolate was genetically similar to other isolates from the Caribbean, suggesting that B.
Nathan E. Stone, Carina M. Hall, A. Springer Browne, Jason W. Sahl, Shelby M. Hutton, Ella Santana-Propper, Kimberly R. Celona, Irene Guendel, Cosme J. Harrison, Jay E. Gee, Mindy G. Elrod, Joseph D. Busch, Alex R. Hoffmaster, Esther M. Ellis, David M. Wagner   +14 more
doaj   +1 more source

Bilateral Pneumothorax-rare Manifestation of Melioidosis [PDF]

Journal of Clinical and Diagnostic Research, 2018
Melioidosis is caused by gram negative bacilli called Burkholderia pseudomallei. It is an infectious threat to southeast Asian population. It predominantly affects the diabetic people who have got exposure to the contaminated soil. As it affects multiple
Allen Aloysius D’silva, Jayasenan Jayannan, Ali Hazan Karnam, Sanjay R Nair, Natarajan Vasanthi   +4 more
doaj   +1 more source

Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei. [PDF]

, 2017
Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is correlated with poor clinical outcomes.
A Easton, A Haque, A Novikov, A O’Garra, AC Cheng, AJ Simpson, BJ Currie, C Kewcharoenwong, CA Rowland, CR Romero, D Limmathurotsakul, D Limmathurotsakul, D Limmathurotsakul, D Suwannasaen, FN Lauw, G Lertmemongkolchai, GC Koo, GC Ulett, GC Ulett, GCKW Koh, GCKW Koh, J Chen, J Morris, J-X See, JM Pitt, JR Teijaro, JU Igietseme, K Breitbach, KA Hodgson, KN Couper, KS Tan, KW Moore, L Conejero, M Kortylewski, M Saraiva, MJ Greenberger, MM Kane, MP Moutschen, MTG Holden, N Chantratita, N White, P Saengmuang, P Santanirand, P Tippayawat, P Trzonkowski, PS Redford, R Sabat, S Chanchamroen, SA Dalrymple, TAF Weehuizen, V Wuthiekanun, W Aekplakorn, WJ Wiersinga, Y Homma, Y Suputtamongkol   +54 more
core   +1 more source

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

Immunology, Volume 177, Issue 2, Page 254-269, February 2026.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco, Itziar Martín‐Ruiz, Sarai Araujo‐Aris, Diego Barriales, Janire Castelo, Leire Egia‐Mendikute, Monika Gonzalez, Jose Ezequiel Martin, Elena Molina, Maitane Mugica, Ainhoa Palacios, Iratxe Seoane, Naiara Gutiez, Estibaliz Atondo, Eneko Santos Fernández, Maddi Oyanguren, Borja Jimenez‐Lasheras, Ainize Peña‐Cearra, Ana M. Aransay, Asis Palazon, Aize Pellón, Leticia Abecia, Hector Rodriguez, Natalia Elguezabal, Juan Anguita   +24 more
wiley   +1 more source

Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells [PDF]

, 2015
Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp.
Graeme C. Clark, Jonathan David, Rachel E. Bell   +2 more
core   +1 more source

Intra‐ and Intermolecular Glycosylation of d‐Idopyranosyl and 6‐Deoxy‐d‐ido‐heptopyranosyl Donors: Toward the Repeating Unit of Campylobacter jejuni HS:4c Capsular Polysaccharide

European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
A comprehensive glycosylation study of diversely protected and activated d‐idopyranosyl and 6‐deoxy‐d‐ido‐heptopyranosyl donors using intra‐ and intermolecular coupling strategies is reported. Intramolecular aglycon delivery afforded 1,2‐cis‐β‐idopyranosides, while intermolecular glycosylation yielded chromatographically separable α‐ and β‐linked ...
Maude Cloutier, Nitish Verma, Ilona Douchez, Charles Gauthier   +3 more
wiley   +1 more source