Role of RelA and SpoT in Burkholderia pseudomallei Virulence and Immunity [PDF]
Burkholderia pseudomallei is a Gram-negative soil bacterium and the causative agent of melioidosis, a disease of humans and animals. It is also listed as a category B bioterrorism threat agent by the U.S.
Wand, ME +11 more
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Burkholderia pseudomallei causes melioidosis. Sequence typing this pathogen can reveal geographical origin and uncover epidemiological associations. Here, we describe B.
Heather P McLaughlin +2 more
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Phenotypic and Functional Characterization of Human Memory T Cell Responses to Burkholderia pseudomallei [PDF]
Copyright: © 2009 Tippayawat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Direk Limmathurotsakul +40 more
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T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis. [PDF]
There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and Northern Australia.
Sumonwiriya, M +41 more
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An unusual case of primary melioidotic prostatic abscess complicated by perianal abscess
Burkholderia pseudomallei is recognized to cause severe and fatal infections. Most of the infections caused by this facultative intracellular gram-negative bacterium are pneumonia, soft tissue, genito-urinary and central nervous system infection.
Y.C. Chee, Y.N. Chee
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Efflux Pump-mediated Drug Resistance in Burkholderia
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky +4 more
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Diverse Burkholderia Species Isolated from Soils in the Southern United States with No Evidence of B. pseudomallei. [PDF]
The global distribution of the soil-dwelling bacterium Burkholderia pseudomallei, causative agent of melioidosis, is poorly understood. We used established culturing methods developed for B.
Carina M Hall +11 more
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Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy [PDF]
Whole-genome sequencing of the four isolates used in this study was supported by Wellcome Trust grant 098051, awarded to the Wellcome Trust Sanger Institute.
Theobald, V +38 more
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Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.
BACKGROUND: We aimed to determine the antibody and T cell responses to Burkholderia pseudomallei of humans to select candidate vaccine antigens. METHODS: For antibody profiling, a protein microarray of 154 B.
Richard W. Titball +26 more
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Glyburide reduces bacterial dissemination in a mouse model of melioidosis [PDF]
Background: Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ,40% mortality rate despite antimicrobial chemotherapy. We showed in a
Krause, Kathrin +55 more
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