Results 61 to 70 of about 13,156 (133)

Double‐Duty Drugs: Repositioning Antipsychotics to Combat Bacterial Infections

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Antipsychotics can exert antibacterial effects via several mechanisms: (1, 2) Due to their amphiphilic and cationic characteristics, antipsychotics can negatively affect the integrity of the plasma membrane by disrupting its structure and electrochemical potential.
Navid Faraji, Mohammad Abavisani, Negar Ebadpour, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

Immunology, Volume 177, Issue 2, Page 254-269, February 2026.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco, Itziar Martín‐Ruiz, Sarai Araujo‐Aris, Diego Barriales, Janire Castelo, Leire Egia‐Mendikute, Monika Gonzalez, Jose Ezequiel Martin, Elena Molina, Maitane Mugica, Ainhoa Palacios, Iratxe Seoane, Naiara Gutiez, Estibaliz Atondo, Eneko Santos Fernández, Maddi Oyanguren, Borja Jimenez‐Lasheras, Ainize Peña‐Cearra, Ana M. Aransay, Asis Palazon, Aize Pellón, Leticia Abecia, Hector Rodriguez, Natalia Elguezabal, Juan Anguita   +24 more
wiley   +1 more source

Intra‐ and Intermolecular Glycosylation of d‐Idopyranosyl and 6‐Deoxy‐d‐ido‐heptopyranosyl Donors: Toward the Repeating Unit of Campylobacter jejuni HS:4c Capsular Polysaccharide

European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
A comprehensive glycosylation study of diversely protected and activated d‐idopyranosyl and 6‐deoxy‐d‐ido‐heptopyranosyl donors using intra‐ and intermolecular coupling strategies is reported. Intramolecular aglycon delivery afforded 1,2‐cis‐β‐idopyranosides, while intermolecular glycosylation yielded chromatographically separable α‐ and β‐linked ...
Maude Cloutier, Nitish Verma, Ilona Douchez, Charles Gauthier   +3 more
wiley   +1 more source

Melioidosis Caused by Burkholderia pseudomallei in Drinking Water, Thailand, 2012

Emerging Infectious Diseases, 2014
We identified 10 patients in Thailand with culture-confirmed melioidosis who had Burkholderia pseudomallei isolated from their drinking water. The multilocus sequence type of B.
Direk Limmathurotsakul, Gumphol Wongsuvan, David Aanensen, Sujittra Ngamwilai, Natnaree Saiprom, Patpong Rongkard, Janjira Thaipadungpanit, Manas Kanoksil, Narisara Chantratita, Nicholas P.J. Day, Sharon J. Peacock   +10 more
doaj   +1 more source

Influence of Biochemical Features of Burkholderia pseudomallei Strains on Identification Reliability by Vitek 2 System

Journal of Global Infectious Diseases, 2018
Background: Burkholderia pseudomallei is a Gram-negative saprophytic soil bacterium that causes melioidosis, a potentially fatal disease endemic in wet tropical areas.
Irina B Zakharova, Yana A Lopasteyskaya, Andrey V Toporkov, Dmitry V Viktorov   +3 more
doaj   +1 more source

Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp

mSphere, 2019
Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public
Robert J. Hogan, Eric R. Lafontaine
doaj   +1 more source

Multiplex qPCR for reliable detection and differentiation of Burkholderia mallei and Burkholderia pseudomallei

BMC Infectious Diseases, 2013
Background Burkholderia mallei and B. pseudomallei are two closely related species of highly virulent bacteria that can be difficult to detect. Pathogenic Burkholderia are endemic in many regions worldwide and cases of infection, sometimes brought by ...
Janse Ingmar, Hamidjaja Raditijo A, Hendriks Amber CA, van Rotterdam Bart J   +3 more
doaj   +1 more source

Sequence-Defined Transposon Mutant Library of Burkholderia thailandensis

mBio, 2013
We constructed a near-saturation transposon mutant library for Burkholderia thailandensis, a low-virulence surrogate for the causative agent of melioidosis (Burkholderia pseudomallei). A primary set of nearly 42,000 unique mutants (~7.5 mutants/gene) was
Larry A. Gallagher, Elizabeth Ramage, Rapatbhorn Patrapuvich, Eli Weiss, Mitch Brittnacher, Colin Manoil   +5 more
doaj   +1 more source

Burkholderia pseudomallei Evades Nramp1 (Slc11a1)- and NADPH Oxidase-Mediated Killing in Macrophages and Exhibits Nramp1-Dependent Virulence Gene Expression

Frontiers in Cellular and Infection Microbiology, 2017
Bacterial survival in macrophages can be affected by the natural resistance-associated macrophage protein 1 (Nramp1; also known as solute carrier family 11 member a1 or Slc11a1) which localizes to phagosome membranes and transports divalent cations ...
Veerachat Muangsombut, Patoo Withatanung, Varintip Srinon, Varintip Srinon, Narisara Chantratita, Mark P. Stevens, Jenefer M. Blackwell, Jenefer M. Blackwell, Sunee Korbsrisate   +8 more
doaj   +1 more source

Virulence of Burkholderia pseudomallei Strains from Western Hemisphere and Africa in Mice. [PDF]

Emerg Infect Dis
Klimko CP, Meinig JM, Mlynek KD, Rill NO, Biryukov SS, Dankmeyer JL, Gray AM, Chua J, Halasahoris SA, Davies ML, Smith BA, Rodriguez-Negron CI, Braun CT, Martinez EE, Spencer JL, Dyer DN, Frick OM, Torres ME, Elrod MG, Gee JE, Gulvik CA, Weiner ZP, Qiu J, Bozue JA, DeShazer D, Cote CK.   +25 more
europepmc   +1 more source