Results 61 to 70 of about 16,054 (178)

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Bilateral Pneumothorax-rare Manifestation of Melioidosis [PDF]

Journal of Clinical and Diagnostic Research, 2018
Melioidosis is caused by gram negative bacilli called Burkholderia pseudomallei. It is an infectious threat to southeast Asian population. It predominantly affects the diabetic people who have got exposure to the contaminated soil. As it affects multiple
Allen Aloysius D’silva, Jayasenan Jayannan, Ali Hazan Karnam, Sanjay R Nair, Natarajan Vasanthi   +4 more
doaj   +1 more source

AI‐Enabled Imaging for Pathogen Detection Under Stress Conditions: A Systematic Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Advances in pathogen detection that incorporate artificial intelligence (AI) may capture microbial signals under challenging environmental conditions that traditional methods miss. This systematic review evaluates the application, performance, and methodological characteristics of AI‐enabled imaging for pathogen detection, including its impact
MeiLi Papa, Gillian Kuehnle, Yoo Jung (Erika) Oh, Jiyoon Yi   +3 more
wiley   +1 more source

The possibility of identifying individual strains of glanders and melioidosis pathogens with a combination of immunoblotting and DNA amplification methods

Инфекция и иммунитет, 2019
Causative agents of melioidosis and glanders are among the most dangerous bacterial pathogens for human. Moreover, Burkholderia pseudomallei and Burkholderia mallei are considered to be potential bioterrorism agents.
S. S. Vetchinin, I. Yu. Shchit, A. G. Shevyakov, S. F. Biketov   +3 more
doaj   +1 more source

Glutathione Impacts Both Batrachochytrium dendrobatidis Virulence and Amphibian Cellular Defense in a Chytridiomycosis Model

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Glutathione shapes interactions between Batrachochytrium dendrobatidis (Bd) and amphibian hosts. In Bd, glutathione reductase is essential for survival, and exogenous glutathione enhances zoospore release. In host cells, Bd infection depletes glutathione and increases oxidative stress.
Rebecca J. Webb, Alexandra A. Roberts, Lee Berger, Jacques Robert, Lee F. Skerratt   +4 more
wiley   +1 more source

Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis.

, 2011
Burkholderia pseudomallei is the etiological agent of human melioidosis, a disease with a broad spectrum of clinical manifestations ranging from fatal septicemia to chronic localized infection or asymptomatic latent infection.
Patel, Natasha, Richard W. Titball, Prior, J, Salguero, FJ, Laura Conejero, Oberdorf, Sara, de Reynal, M, Titball, RW, Francisco J. Salguero, Gregory J. Bancroft, Joanne Prior, Prior, Joanne, Natasha Patel, Philip L. Felgner, Oberdorf, S, Conejero, L, Titball, Richard W, Felgner, Philip L, Conejero, Laura, Salguero, Francisco J, Felgner, PL, Bancroft, GJ, Melanie de Reynal, Sara Oberdorf, Bancroft, Gregory J, de Reynal, Melanie, Patel, N   +26 more
core   +1 more source

Production of Monoclonal Antibodies against Outer Membrane Proteins of Burkholderia pseudomallei, Strain C-141

Проблемы особо опасных инфекций, 2008
Monoclonal antibodies (MAb) were produced against two B. pseudomallei high-purified membrane proteins with Mr 29 kDa (p29) and 45 kDa (p45). Monoclonal antibodies from culture supernatant fluids of 4F2 and 1G11 clones showed specific interaction with ...
S. S. Vetchinin, P. C. Kopylov, N. V. Kiseleva, A. M. Baranov, E. V. Baranova, E. V. Galkina, A. I. Borzilov, I. Y. Kalachev   +7 more
doaj   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, Volume 293, Issue 8, Page 2225-2247, April 2026.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Burkholderia pseudomallei genome plasticity associated with genomic island variation

, 2008
SJP was supported by a Wellcome Trust Career Development Award in Clinical Tropical Medicine. This study was funded by the Wellcome Trust.Background: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis.
Direk Limmathurotsakul, William C Nierman, Mongkol Vesaratchavest, Vesaratchavest, Mongkol, Nierman William C, Nierman, WC, Limmathurotsakul Direk, Peacock Sharon J, Chierakul, Wirongrong, Chierakul Wirongrong, Nicholas PJ Day, Nierman, William C., Day Nicholas PJ, Vesaratchavest, M, Holden, Matthew T. G., Wirongrong Chierakul, Feil, Edward J., Peacock, Sharon J., Peacock, SJ, Currie, B J, Wuthiekanun, V, Tumapa Sarinna, Matthew TG Holden, Holden, M T G, Holden Matthew TG, Currie, BJ, Tumapa, S, Feil Edward J, Feil, EJ, Wuthiekanun Vanaporn, Sharon J Peacock, Day, Nicholas P. J., Peacock, S J, Day, NP, Nierman, W C, Holden, MT, Currie Bart J, Day, N P J, Limmathurotsakul, Direk, Limmathurotsakul, D, Tumapa, Sarinna, Wuthiekanun, Vanaporn, Edward J Feil, Vesaratchavest Mongkol, Currie, Bart J., Sarinna Tumapa, Vanaporn Wuthiekanun, Chierakul, W, Day, Nicholas, Feil, E J, Bart J Currie   +50 more
core   +1 more source

Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications.

PLoS ONE, 2012
The bacterium Burkholderia pseudomallei causes melioidosis, a rare but serious illness that can be fatal if untreated or misdiagnosed. Species-specific PCR assays provide a technically simple method for differentiating B.
Erin P Price, Julia L Dale, James M Cook, Derek S Sarovich, Meagan L Seymour, Jennifer L Ginther, Emily L Kaufman, Stephen M Beckstrom-Sternberg, Mark Mayo, Mirjam Kaestli, Mindy B Glass, Jay E Gee, Vanaporn Wuthiekanun, Jeffrey M Warner, Anthony Baker, Jeffrey T Foster, Patrick Tan, Apichai Tuanyok, Direk Limmathurotsakul, Sharon J Peacock, Bart J Currie, David M Wagner, Paul Keim, Talima Pearson   +23 more
doaj   +1 more source