Results 201 to 210 of about 8,764,696 (266)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

open access: yesAdvanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan   +13 more
wiley   +1 more source

Unlocking Low‐Melting‐Point and High‐Conductivity Molten Salts via High‐Entropy Strategy with Demonstration in Thermal Batteries

open access: yesAdvanced Science, EarlyView.
A high‐entropy strategy is developed to break the trade‐off between low melting point and high ionic conductivity in molten salt electrolytes. By incorporating CsBr and LiF into the LiCl‐LiBr‐KBr system, the quinary LiF‐LiCl‐LiBr‐KBr‐CsBr electrolyte achieves a record‐low melting point of 229.5°C while maintaining a high conductivity of 1.19 S cm−1 at ...
Binchao Shi   +6 more
wiley   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

open access: yesAdvanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu   +12 more
wiley   +1 more source

Beyond Traditional Phenolics: Disulfide Bonds for Performance Enhancement of Aerospace Ablation‐Resistant Materials from Processing to Recycling

open access: yesAdvanced Science, EarlyView.
The dynamic disulfide bonds facilitated the development of high‐performance aerospace ablation‐resistant materials. At moderate temperature, the dissociation and recombination of disulfide bonds ensured excellent processability, mechanical properties, and recycling ability of phenolic resin; at high temperature, cleavage of disulfide bonds produced ...
Yu Li   +9 more
wiley   +1 more source

Bending‐Stable Pressure Sensor Based on Natural Wood Nanofibers for Ultra‐Low Detection Limit

open access: yesAdvanced Science, EarlyView.
A wood nanofiber‐based flexible pressure sensor with intrinsic bending‐stable performance is developed through a porous electrospun architecture and interdigital electrode design. The device exhibits an ultra‐low detection limit and stable operation under deformation for physiological monitoring and spatial sensing, providing a sustainable strategy for
Xu Zeng   +7 more
wiley   +1 more source

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