Results 21 to 30 of about 130,955 (72)

The Interaction Between CitMYB52 and CitbHLH2 Negatively Regulates Citrate Accumulation by Activating CitALMT in Citrus Fruit

Frontiers in Plant Science, 2022
Citric acid plays significant roles in numerous physiological processes in plants, including carbon metabolism, signal transduction, and tolerance to environmental stress.
Sheng-Hung Liu, Xincheng Liu, Bangrui Gou, Deng-Liang Wang, Chun-rong Liu, Jun Sun, Xue-Ren Yin, D. Grierson, Shaojia Li, Kun-Song Chen   +9 more
semanticscholar   +1 more source

Structure and inhibition mechanism of the human citrate transporter NaCT

Nature, 2021
Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1–3.
D. Sauer, Jin-Mei Song, Bing Wang, Jacob Hilton, N. Karpowich, Joseph A. Mindell, W. J. Rice, Da-Neng Wang   +7 more
semanticscholar   +1 more source

Hydration of potassium citrate-activated BOF slag

Cement and Concrete Research, 2021
Basic Oxygen Furnace (BOF) slag is currently utilized with low-grade applications or landfilled. Here, we investigate a novel route to upgrade BOF slag to a high-performance binder by chemical activation with tri-potassium citrate.
A. Kaja, K. Schollbach, S. Melzer, S. R. van der Laan, H. Brouwers, Qing-Liang Q. Yu   +5 more
semanticscholar   +1 more source

Antitussive activity of alcoxyphenyl carbamic acid analogues.

General Physiology and Biophysics, 2018
In this study we report pharmacological evaluation of four newly synthetized analogues of alcoxyphenyl carbamic acid, structurally related to butamirate citrate that is frequently used as cough suppressing drug, and marked as ATK 231, ATK 241, ATK 251 ...
J. Jurečeková, G. Nosál'ová, L. Jurecek, J. Csollei, Veronika Sivová, S. Nosáľ   +5 more
semanticscholar   +1 more source

Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Although current guidelines suggest the use of regional citrate anticoagulation (which involves the addition of a citrate solution to the blood before the filter of the extracorporeal dialysis circuit) as first-line treatment for continuous ...
A. Zarbock, M. Küllmar, D. Kindgen-Milles, C. Wempe, J. Gerss, T. Brandenburger, T. Dimski, B. Tyczynski, M. Jahn, N. Mülling, M. Mehrländer, P. Rosenberger, G. Marx, T. Simon, U. Jaschinski, P. Deetjen, C. Putensen, J. Schewe, S. Kluge, D. Jarczak, T. Slowinski, M. Bodenstein, P. Meybohm, S. Wirtz, O. Moerer, A. Kortgen, P. Simon, S. Bagshaw, J. Kellum, M. Meersch   +29 more
semanticscholar   +1 more source

Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis

Aging Cell, 2021
Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood ...
Shou-Zen Fan, Cheng-Sheng Lin, Yu-wen Wei, Sheng-Rong Yeh, Yi-Hsuan Tsai, Andrew C. Lee, Wei-Sheng Lin, Pei-Yu Wang   +7 more
semanticscholar   +1 more source

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.

Immunity, 2019
Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades. Whether concurrent changes in the cellular metabolism that occur upon TLR activation influence the quality of the
M. Lauterbach, Jasmin Hanke, Magdalini Serefidou, M. Mangan, C. Kolbe, T. Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, J. Gehlen, G. Engels, Maike Kreutzenbeck, S. Schmidt, A. Christ, A. Imhof, K. Hiller, E. Latz   +16 more
semanticscholar   +1 more source

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

Frontiers in Immunology, 2018
Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can ...
Niamh C. Williams, L. O'Neill
semanticscholar   +1 more source

Citrate Coordination and Bridging of Gold Nanoparticles: The Role of Gold Adatoms in AuNP Aging

ACS Nano, 2020
Gold nanoparticles used in many types of nanostructure are mostly stabilized by citrate ligands. Fully understanding their dynamic surface chemistry is thus essential for applications, particularly since aging is frequently a problem.
David-Benjamin Grys, B. de Nijs, Andrew R. Salmon, Junyang Huang, Wenting Wang, Wei-Hsin Chen, O. Scherman, J. Baumberg   +7 more
semanticscholar   +1 more source

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Nature Communications, 2020
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage
J. Baardman, S. Verberk, S. van der Velden, M. Gijbels, C. van Roomen, J. Sluimer, J. Broos, G. Griffith, K. Prange, M. van Weeghel, S. Lakbir, D. Molenaar, E. Meinster, A. Neele, G. Kooij, H. D. de Vries, E. Lutgens, K. Wellen, M. de Winther, J. van den Bossche   +19 more
semanticscholar   +1 more source