Results 31 to 40 of about 3,321 (280)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Metabolomics analysis of sodium butyrate's effects on lipid metabolism in lambs' rumen-blood-muscle axis

Journal of Agriculture and Food Research
This study employed metabolomics approaches to systematically elucidate the key pathways and regulatory mechanisms by which sodium butyrate modulated fatty acid metabolism in ruminants, thereby addressing the knowledge gap regarding its roles in fatty ...
Yue Zhang, Hongbo Qu, Min Zhang, Yueying Guo, Lin Su, Lihua Zhao, Lina Sun, Yin Jin   +7 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats Glutamina pura ou combinada com ácidos graxos de cadeia curta não melhora a capacidade adaptativa do intestino após enterectomia extensa em ratos

Acta Cirúrgica Brasileira, 2006
PURPOSE: To investigate the effect of oral glutamine alone or combined with short chain fatty acids (SCFA) in the intestinal adaptation of rats submitted to an massive enterectomy.
José de Souza Neves, José Eduardo de Aguilar-Nascimento, Maria Helena Gaiva Gomes-da-Silva, Rosecélia Nunes Cavalcanti, Alberto Salomão Bicudo, Mariana Nascimento, Rubens Jardim Nochi Jr.   +6 more
doaj   +1 more source

Enzymatic Resolution of Ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrate by Pseudomonas Cepacia Lipase Catalyzed Acetylation

, 2007
Enzymatic resolution of a series of enantiomerically pure ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrates was performed using Pseudomonas Cepacia lipase (EC 3.1.1.3) as a catalyst.
TOLOMELLI, ALESSANDRA, GENTILUCCI, LUCA, CARDILLO, GIULIANA, MOSCONI, ELISA, BENFATTI, FIDES   +4 more
core   +1 more source

Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases

, 2009
(R)-2-Tetralol (R)-2a, (R)-5-hydroxy-2-tetralol (R)-2b and (R)-8-hydroxy-2-tetralol (R)-2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99%
M. Pregnolato, G. Speranza, M. Filice, I. Nieto, C. F. Morelli, P. Bonomi, P. Manitto, D. Ubiali, M. Terreni, P. Cairoli   +9 more
core   +2 more sources

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, EarlyView.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Methyl, ethyl, isopropyl and tert-butyl 3-oxo-2-(triphenylphosphoranylidene)butyrates, a common pattern a preferred conformation [PDF]

, 2001
The crystal structures of four alkyl 3-oxo-2-(triphenylphosphoranylidene)butyrates, where the alkyl group is methyl (C23H21O3P .0.5C(6)H(6)), (II), ethyl (C24H23O3P), (III), isopropyl (C25H25O3P), (IV), or tert-butyl (C26H27O3P), (V), show all of them to
Bunton, Clifford A., Castañeda Magliona, Fernando, Garland, María Teresa, Terraza, C. A., Baggio, Ricardo   +4 more
core  

Comparison Study of YBa₂Cu₃O_7-x Films Deposited by Using Various Carboxylate Solutions

, 2015
In this work, four fluorine-free solutions based on various carboxylates (propionates, butyrates, valerates, and hexanoates, respectively) were prepared and used for deposition of YBCO films on LaAlO3 single-crystal substrates, in order to further ...
Wulff, Anders Christian, Norby, Poul, Yue, Zhao, Grivel, Jean-Claude, Torres, P.   +4 more
core   +1 more source