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α-Glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of phenolic compounds from Carthamus tinctorius L. flowers: In silico and in vitro studies. [PDF]
Saudi Pharm JAlotaibi JAM +9 more
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Butyrylcholinesterase levels correlate with surgical site infection risk and severity after colorectal surgery: a prospective single-center study. [PDF]
Front SurgVerras GI, Mulita F.
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The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2008 Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity.
Michaela Carlson +3 more
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Butyrylcholinesterase deficiency
Annales de biologie clinique, 2016Butyrylcholinesterase (EC 3.1.1.8; BChE) is a sister enzyme of acetylcholinesterase. Though BChE lacks obvious physiological functions, it is of toxicological and pharmacological importance in detoxifying or catabolising ester-containing drugs. Furthermore, individuals deficient in BChE appear asymptomatic, apart from a heightened sensitivity to the ...
Sébastien Courcelle +4 more
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Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase [PDF]
Chemistry - A European Journal, 2019 AbstractOrganophosphorus (OP) nerve agents and pesticides present significant threats to civilian and military populations. OP compounds include the nefarious G and V chemical nerve agents, but more commonly, civilians are exposed to less toxic OP pesticides, resulting in the same negative toxicological effects and thousands of deaths on an annual ...
Andrew J Franjesevic +2 more
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Neurobiology of butyrylcholinesterase
Nature Reviews Neuroscience, 2003Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function.
Sultan Darvesh +2 more
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A mechanistic model for butyrylcholinesterase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1979A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
Håkan Eriksson +1 more
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