Results 181 to 190 of about 11,286 (211)
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Butyrylcholinesterase deficiency
Annales de biologie clinique, 2016Butyrylcholinesterase (EC 3.1.1.8; BChE) is a sister enzyme of acetylcholinesterase. Though BChE lacks obvious physiological functions, it is of toxicological and pharmacological importance in detoxifying or catabolising ester-containing drugs. Furthermore, individuals deficient in BChE appear asymptomatic, apart from a heightened sensitivity to the ...
Hervé, Delacour +4 more
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Neurobiology of butyrylcholinesterase
Nature Reviews Neuroscience, 2003Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function.
Sultan, Darvesh +2 more
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Butyrylcholinesterase in metabolic syndrome
Medical Hypotheses, 2010Butyrylcholinesterase may have a role in a number of metabolic functions and could affect the expression of insulin resistance syndrome. We present our integrated work using clinical, biochemical and bioinformatic approaches to delineate the possible function of this enzyme.
Gumpeny R, Sridhar +11 more
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Butyrylcholinesterase formulated in liposomes
Biotechnology and Applied Biochemistry, 1999Exogenous cholinesterases have the potential to take part in defence against organophosphate toxins, by acting as scavenger systems. Postulating that formulation in liposomes could enhance the toxin‐scavenging potential of these enzymes, we have initiated studies of such formulations and are reporting here our first steps, exploring ...
I, Schumacher, A, Arad, R, Margalit
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‘Inverse’ substrates for butyrylcholinesterase
Biochimica et Biophysica Acta (BBA) - Enzymology, 19801. 'Inverse'-type substrates for butyrylcholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), i.e., p- and o-nitrophenyl esters of (3-carboxypropyl)-trimethylammonium iodide, (4-carboxybutyl)trimethylammonium iodide and (5-carboxypentyl)trimethylammonium iodide were prepared, and their kinetic parameters for butyrylcholinesterase-catalyzed hydrolysis
M, Nozawa, K, Tanizawa, Y, Kanaoka
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Resveratrol Derived Butyrylcholinesterase Inhibitors
Archiv der Pharmazie, 2013Novel polyhydroxylated (E)‐stilbenes were synthesized by Mizoroki–Heck reactions and tested for their ability to inhibit the enzymes acetyl‐ and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94‐fold stronger inhibitor of butyrylcholinesterase than of ...
René, Csuk +3 more
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Imaging Butyrylcholinesterase in Multiple Sclerosis
Molecular Imaging and Biology, 2020Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). BChE activity is present in white matter and localizes to activated microglia associated with MS lesions. The purpose of this study
M. W. D. Thorne +6 more
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A mechanistic model for butyrylcholinesterase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1979A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
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