Results 191 to 200 of about 11,286 (211)
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The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency
The Journal of Pharmacology and Experimental Therapeutics, 2008Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity.
Bin, Li +3 more
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Butyrylcholinesterase (Pseudocholinesterase) Deficiency
2023Abstract Pseudocholinesterase is a plasma enzyme that functions to hydrolyze esters in succinylcholine, mivacurium, and ester-type local anesthetic. Pseudocholinesterase is produced in the liver and exists as an α2-globulin. Pseudocholinesterase deficiency is a rare disorder that can be acquired or inherited.
Brian Harris, Kris Ferguson
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Butyrylcholinesterase activity in schizophrenic patients
Annales de biologie clinique, 2011Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders. The aim of our work was to study BChE activity variations in schizophrenic patients and to investigate the involvement of this enzyme in schizophrenia and the importance of determining its activity in this ...
Hajer, Mabrouk +6 more
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Monoclonal antibodies to mouse butyrylcholinesterase
Chemico-Biological Interactions, 2013Our immunization strategy introduced recombinant mouse butyrylcholinesterase (BChE) to naïve BChE knockout mice. An extraordinarily strong immune reaction gave rise to a whole spectrum of antibodies with different properties. Two selective and highly efficient monoclonal anti-mouse BChE antibodies 4H1 (IgG1) and 4 C9 (IgG2a), with Kd values in the ...
Katarina, Mrvova +4 more
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Butyrylcholinesterase inhibitory guaianolides fromAmberboa ramosa
Archives of Pharmacal Research, 2005Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14 ...
Sher Bahadar, Khan +7 more
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Ionisation of horse serum butyrylcholinesterase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1970Abstract The effect of pH on horse serum cholinesterase (acylcholine acyl-hydrolase, EC 3.1.1.8) catalyzed o- nitrophenyl butyrate hydrolysis shows a non-competitive type of inhibition. The K m value is independent of the pH of the medium, and may be regarded as the true dissociation constant of the ES complex. Its value varies only
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An improved method for butyrylcholinesterase phenotyping
Biochemical Genetics, 1994An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses alpha-naphthyl acetate as substrate and DL-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested ...
G, Picheth +4 more
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Some radiometric microassays for butyrylcholinesterase
Analytical Biochemistry, 1978Abstract A simple method for purifying [ 14 C]butyrylcholine and incubation conditions suitable for estimating butyrylcholinesterase activity are described. Solvent extraction and anion- and cation-exchange procedures for separating butyrylcholine from butyric acid are described and compared.
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Histidine Modification of Human Serum Butyrylcholinesterase
Biochemical and Molecular Medicine, 1997The effects of histidine-modifying reagents on human serum butyrylcholinesterase (BChE) were investigated. The commercially available enzyme was further purified by chromatography on a Sepharose CI-6B column prior to use. In the modification studies, we found that the histidine-specific reagents tosylphenylalanine chloromethyl ketone (TPCK) and ...
D, Cengiz +3 more
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