Results 191 to 200 of about 10,504 (228)

Butyrylcholinesterase formulated in liposomes

Biotechnology and Applied Biochemistry, 1999
Exogenous cholinesterases have the potential to take part in defence against organophosphate toxins, by acting as scavenger systems. Postulating that formulation in liposomes could enhance the toxin‐scavenging potential of these enzymes, we have initiated studies of such formulations and are reporting here our first steps, exploring ...
Ilana Schumacher, Aya Arad, Rimona Margalit   +2 more
openaire   +3 more sources

Butyrylcholinesterase in metabolic syndrome

Medical Hypotheses, 2010
Butyrylcholinesterase may have a role in a number of metabolic functions and could affect the expression of insulin resistance syndrome. We present our integrated work using clinical, biochemical and bioinformatic approaches to delineate the possible function of this enzyme.
Dasika Suryanarayna, Sali Veeresh Kumar, Tatavarthi Uma Devi, Dowluru Svgk Kaladhar, Gumpeny Lakshmi, K. Srinivas, Turaga Nitesh, Padmanabhuni Venkata Nageswara Rao, Allam Appa Rao, GR Sridhar, Gumpeny Nirmala, T. Hanuman   +11 more
openaire   +3 more sources

‘Inverse’ substrates for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
1. 'Inverse'-type substrates for butyrylcholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), i.e., p- and o-nitrophenyl esters of (3-carboxypropyl)-trimethylammonium iodide, (4-carboxybutyl)trimethylammonium iodide and (5-carboxypentyl)trimethylammonium iodide were prepared, and their kinetic parameters for butyrylcholinesterase-catalyzed hydrolysis
Yuichi Kanaoka, Kazutaka Tanizawa, Masayuki Nozawa   +2 more
openaire   +3 more sources

Imaging Butyrylcholinesterase in Multiple Sclerosis

Molecular Imaging and Biology, 2020
Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). BChE activity is present in white matter and localizes to activated microglia associated with MS lesions. The purpose of this study
Ian R. Pottie, Ian R. Pottie, Sultan Darvesh, Sultan Darvesh, Meghan K. Cash, Darcy E. Burley, George Andrew Reid, D Luke, M W D Thorne   +8 more
openaire   +2 more sources

An improved method for butyrylcholinesterase phenotyping

Biochemical Genetics, 1994
An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses alpha-naphthyl acetate as substrate and DL-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested ...
Geraldo Picheth, Eleidi A. Chautard-Freire-Maia, S. L. Primo-Parmo, Cyntia M.T. Fadel-Picheth, Muriel M. Vieira   +4 more
openaire   +3 more sources

Butyrylcholinesterase as a Blood Biomarker in Neuroblastoma

Journal of Pediatric Hematology/Oncology, 2017
Blood-based biomarkers are important in the detection of the disease and in the assessment of responses to therapy. In this study, butyrylcholinesterase was evaluated as a potential biomarker in newly diagnosed neuroblastoma (NB) patients at diagnosis and longitudinally during treatment.
Zbigniew P. Kortylewicz, Angela D. Boettner, Janina Baranowska-Kortylewicz, Jake A. Luther, Don W. Coulter, Stephen P. Enke, Vivek Verma   +6 more
openaire   +3 more sources

Interaction of Exogenous Butyrylcholinesterase with β-Amyloid Plaques in 5XFAD/Butyrylcholinesterase-Knockout Mouse Brain

Current Alzheimer Research, 2021
Background: In Alzheimer’s disease (AD), and amyloid models such as the 5XFAD mouse, butyrylcholinesterase (BChE) is associated with β-amyloid (Aβ) plaques and has unique biochemical features which distinguish it from that found in neurons. It has been suggested that BChE associated with Aβ plaques may be involved in the maturation of this structure ...
Sultan Darvesh, George Andrew Reid
openaire   +3 more sources

Thermal inactivation of butyrylcholinesterase and acetylcholinesterase

Journal of Protein Chemistry, 1993
Differences were observed in the extent of thermal inactivation of human butyrylcholinesterase (BuChE) and eel acetylcholinesterase (AChE). BuChE was more resistant to 57 degrees C inactivation than was AChE. Thermal inactivation of BuChE was reversible and followed first-order kinetics.
Sharon L. Oxendine, Sybil K. Burgess
openaire   +3 more sources

Monoclonal antibodies to mouse butyrylcholinesterase

Chemico-Biological Interactions, 2013
Our immunization strategy introduced recombinant mouse butyrylcholinesterase (BChE) to naïve BChE knockout mice. An extraordinarily strong immune reaction gave rise to a whole spectrum of antibodies with different properties. Two selective and highly efficient monoclonal anti-mouse BChE antibodies 4H1 (IgG1) and 4 C9 (IgG2a), with Kd values in the ...
Lucia Obzerova, Emmanuelle Girard, Eric Krejci, Katarina Mrvova, Anna Hrabovska   +4 more
openaire   +3 more sources

Butyrylcholinesterase activity in schizophrenic patients

Annales de biologie clinique, 2011
Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders. The aim of our work was to study BChE activity variations in schizophrenic patients and to investigate the involvement of this enzyme in schizophrenia and the importance of determining its activity in this ...
Hajer Mabrouk, Wahiba Douki, Anouar Mechri, Haithem Mechria, Houda Rahali, Lotfi Gaha, Mohamed Fadhel Najjar   +6 more
openaire   +3 more sources