Results 101 to 110 of about 60,574,786 (305)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Saudi Pharmaceutical Journal, 2014 In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones are being developed utilizing different sophisticated biotechnological techniques like recombinant DNA technology and protein purification.
Abdul Muheem +7 more
doaj +1 more source
Multi-pass, single-molecule nanopore reading of long protein strands
NatureThe ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited in achieving this goal1,2. Here, we establish a method for the long-range, single-molecule reading of intact protein strands on a commercial nanopore sensor
Keisuke Motone +12 more
openaire +2 more sources
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2018 G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli.
Alexander Bowitch +3 more
doaj +1 more source
Passing the expression hurdle for membrane proteins [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2010 Eric R. Geertsma, Raimund Dutzler
openaire +1 more source
Openness, imperfect exchange rate pass-through and monetary policy [PDF]
This paper analyses the implications of imperfect exchange rate passthrough for optimal monetary policy in a linearised open-economy dynamic general equilibrium model calibrated to euro area data.
Raf Wouters, Frank Smets
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Long-run pass-through from the exchange rate to import prices in African countries [PDF]
, 2006 This paper investigates the extent of pass-through from the nominal exchange rate to import prices for a sample of nineteen African countries. The methodology is based on panel data cointegration testing.
Holmes, Mark J.
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Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Allocation rules for museum pass programs [PDF]
We consider natural axioms for allocating the income of museum pass programs. Two allocation rules are characterized and are shown to coincide with the Shapley value and the equal division solution of the associated TU-game introduced by Ginsburgh and ...
Solal, Philippe, Béal, Sylvain
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