Results 91 to 100 of about 8,127,737 (316)
This study evaluated the physicochemical properties, oxidative stability, and endogenous enzyme activities in fresh pork loin from pigs fattened by supplementation of 3 % soybean oil (control), 3 % linseed oil or 3 % linseed oil combined with 0.3 mg/kg ...
Yiming Sun +5 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
This study investigated the effects of preharvest calcium treatments at different developmental stages on the cuticular wax composition of Summer Black grapes and their correlation with fruit storage quality (4 ± 0.5 °C) and reactive oxygen species (ROS)
Yaoying Zeng +9 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Generalizing the Results of Foresight Studies on the Development of Markets for Liquid Hydrocarbons across the World and Forming Consensus Forecast [PDF]
The article is dedicated to the systematization of forecast trends in the development of liquid hydrocarbons across the world, as well as the formation of a consensus forecast for this area of energy use.
Rudyka Viktor I., Lelyuk Oleksіy V.
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
With the increasing annual production of Lentinula edodes, the residues of Lentinus edodes are mass produced and wasted every year. In order to further explore the added value and effective utilization of Lentinus edodes, we studied the lipid-lowering ...
Kangxiao Guo +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy, but no drug intervention has been approved or recommended for this condition.
Yixin Wu +11 more
doaj +1 more source

