Results 151 to 160 of about 205,619 (384)

Clinical trial of safety and antitumor activity of farletuzumab ecteribulin in patients with platinum‐resistant ovarian cancer: Phase I expansion results

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective In the dose‐escalation part of Study 101, which included multiple tumor types, objective responses were observed in 10 of 22 patients across multiple dose levels of farletuzumab ecteribulin (FZEC). We explored the safety/antitumor activity of FZEC in patients with platinum‐resistant ovarian cancer (PROC) from the Study 101 expansion ...
Kan Yonemori, Mayu Yunokawa, Koji Matsumoto, Kazuhiro Takehara, Kosei Hasegawa, Yasuyuki Hirashima, Hidenori Kato, Hiroki Ikezawa, Yohei Otake, Wataru Yusa, Takuma Miura, Shin Nishio   +11 more
wiley   +1 more source

46. Adenoviral-Mediated Gene Transfer of Single Chain Fv 425:sTRAIL Fusion Protein Induces Target Cell Restricted Apoptosis in EGFR-Positive Tumor Cells and a Potent Bystander Effect without Toxicity In Vivo

, 2007

openalex   +1 more source

CAT‐BLAST: Engineered bacteria for robust targeting and elimination of cancer‐associated fibroblasts

iMeta, EarlyView.
Cancer‐associated fibroblasts (CAFs) construct a protective stromal barrier that promotes tumor growth and resistance to therapy. To dismantle this, we developed CAT‐BLAST, an engineered bacterial platform designed to potently eliminate these cells. We engineered a safe, high‐expression E.
Mengdi Xu, Ehsan Hashemi, Hui Gao, Qumar Zaman, Yi Ma, Jufang Wang, Wenjun Mao, Zhuobin Liang   +7 more
wiley   +1 more source

Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis [PDF]

Luciana Polaco Covre, Carlos Henrique Fantecelle, Renan Garcia de Moura, Paola Oliveira Lopes, Isabela Valim Sarmento, Célio Geraldo Freire-de-Lima, Débora Decotè-Ricardo, Herbert Leonel de Matos Guedes, Alessandra Marcia da Fonsceca-Martins, Lucas P. Carvalho, Edgar M. Carvalho, David M. Mosser, Aloísio Falqueto, Arne N. Akbar, Daniel Cláudio Oliveira Gomes   +14 more
openalex   +1 more source

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Nature Cancer, 2020
Ronan Thibaut, Pierre Bost, I. Milo, M. Cazaux, F. Lemaître, Z. Garcia, I. Amit, Béatrice Bréart, Clémence Cornuot, Benno Schwikowski, P. Bousso   +10 more
semanticscholar   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Alcohol’s Effects on the Bystander Decision-Making Model: A Systematic Literature Review [PDF]

, 2023
Tiffany L. Marcantonio, Michelle Haikalis, Chelsea Misquith, Ruschelle M. Leone   +3 more
openalex   +1 more source

Developing Bystander Intervention Skills in Bullying of Gifted Students

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Özel Eğitim Dergisi
Introduction: The purpose of this study is to implement and evaluate the effect of an online psychoeducation program aimed at enhancing bystander intervention skills in bullying of gifted secondary school students.
Seda Sevgili Koçak, Neşe Kurt Demirbaş   +1 more
doaj   +1 more source

The situational Samaritan: How group reputation threat shapes reparatory behavior

Journal of Consumer Psychology, EarlyView.
Abstract Consumers often act to correct the wrongdoings of people close to them, such as family members or friends. The current research demonstrates that consumers may also engage in a variety of reparatory behaviors—from a simple apology to gift‐giving and tipping—to counter the misdeeds of in‐group strangers when their behavior threatens the ...
Julia Von Schuckmann, Lucia S. G. Barros, Grant E. Donnelly, Marco Bertini   +3 more
wiley   +1 more source

Bystanders witnessing social exclusion exhibit reduced physiological responses of empathy: an EEG study [PDF]

Satsuki Torige, Shinobu Yasumuro, Sunao Iwaki   +2 more
openalex   +1 more source