Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan +16 more
wiley +1 more source
Engineering the Future of ADCs in Non-Small Cell Lung Cancer. [PDF]
Oncol ResKim MR, Lau J, Maffezzoli M, Banna GL.
europepmc +1 more source
A Defense of Post‐Viability Abortion
Bioethics, EarlyView.ABSTRACT It is often thought that Thomson's Violinist argument is only applicable before the point of viability. In this paper, I propose that this is not the case, offering a novel defense of post‐viability abortion utilising Thomson's self‐defense framework. I first set out Thomson's Violinist argument and how it interacts with viability.
Jina Kim
wiley +1 more source
Logistic regression and simulation modelling to evaluate survival effects of EMS response time in suspected cardiac arrest. [PDF]
BMC Emerg MedJánošíková Ľ +5 more
europepmc +1 more source
Why Engage Communities in Biomedical Research?
Bioethics, EarlyView.ABSTRACT While community engagement in biomedical research is widely lauded, and many reasons to engage communities have been adduced, it is unclear whether all these reasons are equally important, and, if not, which are most important. Here, I argue that, outside of rare circumstances, community engagement should not be understood as seeking ...
Robert Steel
wiley +1 more source
The Influence of Social Relationships on Third-Party Punishment: The Roles of Relationship Type Congruence and Threat Perception. [PDF]
Behav Sci (Basel)Xiang Z, Zhu Y, Zhang Q, Chen E, Wu X.
europepmc +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
Underuse of bystander defibrillation on females during out-of-hospital cardiac arrest: a retrospective observational study in Aotearoa New Zealand. [PDF]
Resusc PlusTodd VF +6 more
europepmc +1 more source
British Journal of Haematology, EarlyView.Summary Peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS), is a heterogeneous nodal T‐ and natural killer (NK)‐cell lymphoma with limited prognostic biomarkers. A subset of PTCL‐NOS characterized by Epstein–Barr virus (EBV) involvement in tumour cells has recently been recognized as EBV‐positive nodal T‐ and NK‐cell lymphoma (EBV+ nPTCL ...
Hyunseok Yoon +14 more
wiley +1 more source
Bystander and emergency medical service responses to and outcomes of out-of-hospital cardiac arrest among domestic and non-domestic visitors in Japan. [PDF]
Sci RepOmatsu K, Ushimoto T, Inaba H.
europepmc +1 more source