Results 181 to 190 of about 59,531 (264)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The influence of hate speech on adolescents' bystander intention and TNB aggression. [PDF]

J Res Adolesc
Gorostiaga-Marcos N, Cortazar-Enciondo N, Calvete E.   +2 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

sgRNA amount is a limiting factor in adenine base editing using RNA LNPs. [PDF]

Mol Ther Nucleic Acids
Birkenshaw A, Thomson T, Truong MP, Komaki Y, Ramsden N, Timpano A, Huang C, Blakney AK, Kurek DZ, Kulkarni J, Ross CJD.   +10 more
europepmc   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Out-of-Hospital Cardiac Arrest in Portugal - A Call for a Registry Project. [PDF]

Open Access Emerg Med
Caldeira P, Rabiais I, Ladeira L, Alves P.   +3 more
europepmc   +1 more source

The Relational Character of Canadian Nation‐Building Infrastructure in the 21st Century

Canadian Public Administration, EarlyView.
Abstract Infrastructure development is central to Canada's nation‐building process. This article argues that the federal government has recalibrated its nation‐building mandate from unilateral state command to relational orchestration. Through thematic analysis of thirty‐eight policy documents related to three federal infrastructure plans (2007–2016 ...
Alaz Munzur, Katharina Koch
wiley   +1 more source

Different Responses to Premature Atrial Complexes During Wide QRS Complex Tachycardia: What Is the Mechanism? [PDF]

J Innov Card Rhythm Manag
Korkmaz A, Ozeke O, Ozcan Cetin EH, Kara M, Merovci İ, Ozkan C, Ozcan F, Cay S, Aras D, Topaloglu S.   +9 more
europepmc   +1 more source

Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers

Cancer Science, EarlyView.
Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima, Kentaro Jingushi, Takuro Saito, Toshihiro Uemura, Akinaru Yamamoto, Nesrine Sassi, Hiromu Horitani, Shunsuke Inoguchi, Yuki Horibe, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Norio Nonomura   +12 more
wiley   +1 more source

Strategic automated external defibrillator deployment based on geospatial analysis of historical cardiac arrest locations. [PDF]

Int J Cardiol Heart Vasc
Heckard E, Chugh H, Hadduck K, McNally BF, Sovari A, Jui J, Salvucci A, Reinier K, Chugh SS.   +8 more
europepmc   +1 more source