Results 201 to 210 of about 86,809 (257)

Impacts of decriminalization and its subsequent amendment on drug possession incidents and charges in British Columbia, Canada: Interrupted time series analyses (2013–2024)

open access: yesAddiction, EarlyView.
Abstract Background and aims Decriminalization of personal possession of select illegal drugs was implemented in British Columbia, Canada, for a three‐year period starting 31 January 2023; however, following perceived increases in public drug use and disorder, an amendment introduced on 7 May 2024 rolled back key provisions.
Jürgen Rehm   +5 more
wiley   +1 more source

Contesting repression in divided democracies: Can counternarratives reduce support for police violence?

open access: yesAmerican Journal of Political Science, EarlyView.
Abstract Democracies often struggle to contain police violence, which undermines the rule of law and reproduces inequality by targeting marginalized citizens. Yet, scholars have shown that repressive policing enjoys considerable public support. Focusing on Brazil, we demonstrate that attitudes toward police violence mirror polarization between left ...
Yanilda María González, Natán Skigin
wiley   +1 more source

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

open access: yesAllergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti   +18 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

open access: yesAllergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan   +16 more
wiley   +1 more source

Establishment of an out-of-hospital cardiac arrest registry in Penang, Malaysia. [PDF]

open access: yesResusc Plus
Emily Leong KE   +3 more
europepmc   +1 more source

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