Results 31 to 40 of about 59,531 (264)

The bystander effect in rats [PDF]

Science Advances, 2020
In rats as in humans, nonhelping bystanders suppress helping whereas naive bystanders boost helping above individual levels.
Havlik, John L., Sugano, Yuri Y. Vieira, Jacobi, Maura Clement, Kukreja, Rahul R., Jacobi, John H. Clement, Mason, Peggy   +5 more
openaire   +3 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Correlation between personal characteristics and intention to perform bystander Cardiopulmonary Resuscitation

Healthcare in Low-resource Settings
Out-of-hospital cardiac arrest is a major problem globally characterized by poor survival rates, particularly in residential settings. A delay in administering Cardiopulmonary Resuscitation (CPR) can reduce the survival rate, which is currently at 1 in ...
Ikhda Ulya, Ika Setyo Rini, Melati Gusti Dwi Febriani, Azizah Khusnadani Putri, Kumboyono Kumboyono, Dina Dewi Sartika Lestari Ismail, Ayut Merdikawati   +6 more
doaj   +1 more source

Bystander effects and radiotherapy [PDF]

Reports of Practical Oncology & Radiotherapy, 2015
Radiation-induced bystander effects are defined as biological effects expressed after irradiation by cells whose nuclei have not been directly irradiated. These effects include DNA damage, chromosomal instability, mutation, and apoptosis. There is considerable evidence that ionizing radiation affects cells located near the site of irradiation, which ...
Alicia Marín, Margarita Martín, Olga Liñán, Felipe Alvarenga, Mario López, Laura Fernández, David Büchser, Laura Cerezo   +7 more
openaire   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Safe Sport Allies bystander training: developing a multi-layered program for youth sport participants and their coaches to prevent harassment and abuse in local sport clubs

Frontiers in Psychology
Harassment and abuse represent a pervasive and critical problem in sport with far-reaching consequences. Survivors’ testimonials underscore the profound and enduring impact of these experiences at individual, interpersonal, organizational and community ...
Karolien Adriaens, Helena Verhelle, Gjalt-Jorn Ygram Peters, Leen Haerens, Tine Vertommen, Tine Vertommen, Tine Vertommen   +6 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

A Chained Deep Learning Model for Fine-Grained Cyberbullying Detection With Bystander Dynamics

IEEE Access
Accurate detection of cyberbullying on Social Networking Sites (SNSs) is crucial for online safety, especially for individuals impacted by it. Cyberbullying language is often implicit, necessitating a comprehensive analysis of conversational context to ...
Haifa Saleh Alfurayj, Syaheerah Lebai Lutfi, Ramesh Perumal   +2 more
doaj   +1 more source