Results 51 to 60 of about 59,531 (264)

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Psychological Conflicts in Bystander Cardiopulmonary Resuscitation for Out-of-HospitalCardiac-Arrest

International Journal of First Aid Education, 2020
Aim: Bystander cardiopulmonary resuscitation (CPR) plays an important role in saving the lives of out-of-hospital cardiac arrest (OHCA) patients. Although many factors have been suggested as barriers to performing CPR, the psychological processes and ...
doaj   +2 more sources

Use of the “Ru‐1O2‐Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Advanced Science, EarlyView.
ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun, Kaihong Wang, Haifu Sun, Kemei Tao, Xiang Li, Xiuhua Zhao, Shuang Qiu   +6 more
wiley   +1 more source

From Public Access Defibrillator to Personal Access Defibrillator: Proposal of Prompts to Optimize Automated External Defibrillation Use by Laypeople

Eurasian Journal of Emergency Medicine
Aim: This study aimed to assess whether integrating additional prompts to the automated external defibrillator (AED) interface could reduce common errors among untrained laypeople.
Cristian Abelairas-Gómez, Aida Carballo-Fazanes, Clara Painceira-Díaz, Carmen García-Rodríguez, Antonio Rodríguez-Núñez   +4 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

“That’s Not Sexual Harassment, Is It?”: How Understandings of Sexual Harassment Impact Intervention Work

Tidsskrift for Kjønnsforskning
Sexual harassment (SH) is commonly categorized into gender harassment, unwanted sexual attention, and sexual coercion, and can be understood as part of a broader continuum of violence often experienced by women. To better understand why SH persists, this
Brita Bjørkelo, Malin Wieslander, Ulla-Carin Hedin, Linda Lane, Kristian Stampe Nielsen, Anniken Grønstad, Eva Gemzøe Mikkelsen   +6 more
doaj   +1 more source

The use of virtual reality in the study of people's responses to violent incidents

Frontiers in Behavioral Neuroscience, 2009
This paper reviews experimental methods for the study of the responses of people to violence in digital media, and in particular considers the issues of internal validity on the one hand and ecological validity or generalisability of results to events in
Aitor Rovira, David Swapp, Bernhard Spanlang, Bernhard Spanlang, Mel Slater, Mel Slater, Mel Slater   +6 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Childhood unpredictability, expressive suppression, and mindfulness as predictors of bystanders' outsider behaviors in cyberbullying among Chinese undergraduates: a moderated mediation model

Frontiers in Psychology
BackgroundBystanders' outsider behaviors play a vital role in the development and persistence of cyberbullying incidents, a prevalent form of harmful digital engagement.
Rui Chen, Rui Chen, Rui Chen, Dan Ming, Ting Zhou, Xin Hao, Cui-ying Fan   +6 more
doaj   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source