Results 151 to 160 of about 73,132 (261)

7F transradial approach for anterior circulation mechanical thrombectomy: Is it feasible to downsize and maintain consistency? [PDF]

Interv Neuroradiol
Molinaro S, Russo R, Mistretta F, Gambino A, Gava UA, Bergui M.   +5 more
europepmc   +1 more source

Acesso à justiça no Mercosul [PDF]

, 1999
Rodrigues, Horácio Wanderlei
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round. [PDF]

Stem Cell Reports
Hägg A, Wood R, Mochizuki AL, Abberton K, Abranches E, Alvarez-Palomo B, Baptista R, Quintanilha Barbosa RA, Barry J, Carvalho AB, Bennaceur Griscelli A, Campos de Carvalho AC, Chaker D, Chang H, Choi HY, Codinach M, Arán Corbella B, Cowan S, Dickerson SJ, Elwood N, Fan X, Feyeux M, Forrester M, Gaffney A, Guilbert SM, Ha HY, Hirst AJ, Hunter AL, Jamieson LG, Judson RN, Kanemura Y, Kasai-Brunswick TH, Kim JH, Kim H, Kintali M, Krishnan S, Kuebler B, Lau CY, Li W, Mack A, MacLeod MR, Madrid M, Mamiya H, Manache-Alberici L, Mărginean D, Mentre O, Morgan SL, Mountford J, Munir H, Ng SHS, Ogawa H, Oh S, Ohara H, Oono K, Park N, Pereira LV, Pereira da Silva Bezerra I, Podovei AR, Querol S, Raje J, Raya A, Sakamoto S, Sarafian R, Schmit K, Selvitella S, Singh G, Smart MJK, Song J, Stacey G, Sullivan S, Sumida M, Terrenoire C, Tian P, Uhlin E, Vaquero JMA, Veiga A, Vicky Wang JW, Warre-Cornish K, Wood J, Yamamoto A, Zhang G, Hikichi T, Turner M, Falk A.   +83 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Crucial Gram-positive type IV secretion system protein TraF is a structural homolog of type VII secretion system protein EssB/YukC. [PDF]

Microlife
Kuhlmann K, Stallinger A, Michaelis C, Berger TMI, Kohler V, Gesslbauer B, Pavkov-Keller T, Grohmann E, Keller W.   +8 more
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Endurance training-induced changes in heart rate and blood lactate concentration in puppies. [PDF]

Front Vet Sci
Hyytiäinen H, Junnila J, Laitinen-Vapaavuori O, Kyröläinen H.   +3 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts. [PDF]

Stem Cell Res
Harancher MR, Myklebust LK, Sukhwani M, Kanodia C, Sheng Y, Castro CA, Colvin Zielen AM, Orwig KE.   +7 more
europepmc   +1 more source