Results 151 to 160 of about 3,877,567 (286)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cancer Immunotherapy: lights and shadows

Frontiers in Immunology, 2015
María Marcela eBarrio, Estrella Mariel Levy, José Maria Mordoh, José Maria Mordoh   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Differential Effects of a Telemonitoring Platform in the Development of Chemotherapy-Associated Toxicity: A Randomized Trial Protocol

Diagnostics
Chemotherapy requires careful monitoring, but traditional follow-up approaches face significant challenges that were highlighted by the COVID-19 pandemic. Hence, exploration into telemonitoring as an alternative emerged.
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi   +5 more
doaj   +1 more source

Diseño racional y síntesis de nuevos nanosistemas para la detección y el tratamiento selectivo del cáncer de próstata [PDF]

, 2016
El cáncer de próstata es el segundo cáncer más diagnosticado en hombres y a nivel mundial la quinta causa de muerte por cáncer más común en estos. Este dato muestra la necesidad de nuevas terapias para el diagnóstico y el tratamiento del cáncer de ...
Morillo-Velarde Santos, María
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effects on Quality of Life of a Telemonitoring Platform amongst Patients with Cancer (EQUALITE): A Randomized Trial Protocol

Methods and Protocols
Cancer, a pervasive global health challenge, necessitates chemotherapy or radiotherapy treatments for many prevalent forms. However, traditional follow-up approaches encounter limitations, exacerbated by the recent COVID-19 pandemic.
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi   +5 more
doaj   +1 more source

Satisfacción del paciente ambulatorio con su relación médico paciente en el hospital oncológico del Instituto Salvadoreño del Seguro Social : La perspectiva del paciente. [PDF]

, 2011
El cáncer es una enfermedad crónica degenerativa y causa principal de morbilidad y mortalidad conocida a nivel mundial y nacional. Anualmente, según datos de la OMS, se diagnostican 10, 000,000 de nuevos casos de cáncer en el mundo, con una distribución ...
Hernández Avilés, Ana Silvia del Socorro, Menéndez Rivera, Álvaro Gerardo   +1 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Características de las hospitalizaciones por cáncer de mama en el Complejo Asistencial Universitario de Palencia [PDF]

, 2016
Introducción: El cáncer de mama es el tumor maligno más frecuente entre la población femenina. Cabe destacar que la mortalidad por este tipo de cáncer ha descendido notablemente en los últimos años, debido a los avances en los programas de cribado y en ...
Azpeleta Gil, Patricia
core