Results 171 to 180 of about 7,595,633 (393)
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Activación conductual y mindfulness en la experiencia del dolor de mujeres con cáncer de mama
Gaceta Mexicana de OncologíaAntecedentes: El dolor relacionado con cáncer es una experiencia multifactorial que puede afectar en la adherencia al tratamiento y generar malestar psicológico. Los tratamientos psicológicos constantemente usados buscan disminuir tal malestar sin considerar las necesidades adaptativas de las personas con cáncer. Es necesario implementar intervenciones
Mayra García-Reyes +2 more
openaire +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Revista Española de Discapacidad, 2019 El impacto del diagnóstico de cáncer en niños y adolescentes afecta a todas las áreas individuales y familiares desde el momento del diagnóstico colocándolos en situación de discapacidad.
Jorgina Garrido Casas +4 more
doaj
Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice
Cell Communication and SignalingBackground HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay.
Rocío Fuentes-Mateos +8 more
doaj +1 more source
Descripción epidemiológica del cáncer gástrico en chile, 2001-2008. [PDF]
, 2012 46 p.Introducción: El cáncer gástrico es una de las neoplasias más frecuentes en el mundo contemporáneo. En Chile, es la primera causa de muerte por tumores malignos para hombres y la tercera para mujeres.
Icaza Noguera, María Gloria (Prof. Guía) +2 more
core
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Efecto de la infección de Newcastle Disease Virus en distintas fases del ciclo celular [PDF]
, 2016 Trabajo Fin de Máster presentado por la licenciada en Biotecnología Elena Martín Doncel para optar al título de Máster en Biología y Clínica del Cáncer por la Universidad de Salamanca, que ha sido realizado en el Instituto de Biología Molecular y Celular
Martín-Doncel, Elena
core
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source