Results 81 to 90 of about 5,704,490 (283)

Estimates of the global burden of cervical cancer associated with HIV

Lancet Global Health, 2020
Summary Background HIV enhances human papillomavirus (HPV)-induced carcinogenesis. However, the contribution of HIV to cervical cancer burden at a population level has not been quantified.
D. Stelzle, L. F. Tanaka, K. Lee, A. Ibrahim Khalil, I. Baussano, Anoop S. V. Shah, D. McAllister, Sami L. Gottlieb, S. Klug, A. Winkler, F. Bray, R. Baggaley, G. Clifford, N. Broutet, S. Dalal   +14 more
semanticscholar   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Cervical carcinogenesis: the role of co-factors and generation of reactive oxygen species Carcinogénesis cervical: co-factores y antioxidantes

Salud Pública de México, 2003
Several HPV co-factors have been proposed, some more or less consistently associated with cervical dysplasia and cancer risk. More research, using prospective cohort designs, is needed to further describe where in carcinogenesis these factors are working
Anna Giuliano
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Access to Cervical Cytology in Medellín, Colombia during 2006 [PDF]

, 2007
RESUMEN: En países en desarrollo no se han logrado suficientes avances en reducción de la carga de la enfermedad por cáncer cervical, por lo que es importante mejorar la cobertura, condiciones de acceso y efectividad de los programas de tamizaje.
Mejía Mejía, Aurelio Enrique, Valencia Arredondo, Marleny, Tamayo Acevedo, Lucía Stella, Salas Zapata, Walter Alfredo, Restrepo Zea, Jairo Humberto   +4 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Mecanismos de patogenicidad y respuesta inmune de la infección por Chlamydia trachomatis y su relación con cáncer cervical [PDF]

, 2019
Introducción: el cáncer de cuello uterino es uno de los más comunes a nivel mundial, causando más de 200 000 muertes al año. Progresivamente, se ha venido reconociendo a Chlamydia trachomatis como cofactor para el carcinoma cervical junto con el papiloma
Ibarra-Gimbuel, Diana Sofia, Pinzón-Fernández, María Virginia, Burgos-Quenguán, Anderson Stiven, Caldas-Arias, Liliana, Valencia, Cristhian   +4 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Terapia génica con citocinas contra cáncer cervicouterino Gene therapy with cytokines against cervical cancer

Salud Pública de México, 2005
La terapia génica es una excelente alternativa para el tratamiento de muchas enfermedades. La capacidad para manipular el DNA ha permitido dirigir la terapia génica para corregir la función de un gen alterado, aumentar la expresión de un gen o activar la
Víctor Hugo Bermúdez-Morales, Oscar Peralta-Zaragoza, Vicente Madrid-Marina   +2 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source