Results 21 to 30 of about 222,078 (214)

Differences in risk factors, demographic and clinicopathologic characteristics at diagnosis between proximal and distal colon cancer: A multicenter retrospective cohort analysis

Revista de Gastroenterología de México (English Edition)
Introduction and aims: There are differences, with genetic and embryologic support, in the clinical behavior of proximal colon cancer (PCC) (right colon: cecum, ascending colon, and transverse colon) and distal colon cancer (DCC) (left colon: descending ...
R.A. Muñoz, F.J. Miranda, A.A. Ramírez, D. Regalado, J.C. Ortiz, G. Gallardo, S. Pizarro   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour sidedness and clinicopathological features of resected colon cancer in rural population of Northern Pakistan: single institutional analysis

Journal of Coloproctology, 2019
Objectives: Different clinicopathological and molecular features have been demonstrated between right and left sided colon cancers. We aimed to characterize colon cancer and sidedness among a North-Pakistani rural population diagnosed with colon cancer ...
Shah Zeb Khan, MD, Ismat Fatima
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Colon tumor location: Right side versus left side as a prognostic factor for colon cancer survival: Analysis of a retrospective cohort

Revista de Gastroenterología de México (English Edition)
Introduction: Primary tumor location has emerged as an important prognostic factor due to different biologic characteristics. Aim: To analyze the prognostic effect of tumor location in patients with colon cancer, comparing right-sided colon cancer with ...
S.P. Molina-Meneses, L.J. Palacios-Fuenmayor, F.D. Molina-Mercado, D.F. Caycedo-Medina, R. Castaño-Llano, L.R. Gómez-Wolff, Y.E. Pérez-García   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cáncer de colon familiar

Cirugía del Uruguay, 1977
Se presentan dos observaci001es clínicas correspondientes a dos hermanas, que presentaban en forma simultánea, adenocáncer de colon complicado con fístula digestiva, sin lesiones preneoplásicas previas.
Agustín Fronzutti, Luis A. Cazabán, Juan Segura, Carlos Oehninger   +3 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cáncer de colon hereditario

Psicooncologia, 2005
Colorrectal cancer (CCR) is one of the most common cancers worldwide. In developed countries, it is the second most common cancer both in men and women, after breast and lung cancer, respectively.
Ignacio Blanco, Esther Cabrera, Gemma Llort   +2 more
doaj