Results 21 to 30 of about 5,139,728 (295)

Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

BMC Cancer, 2018
Background Resistance to preoperative radiotherapy is a major clinical problem in the treatment for locally advanced rectal cancer. The role of NDRG1 in resistance to ionizing radiation in rectal cancer has not been fully elucidated.
Soon-Chan Kim, Young-Kyoung Shin, Ye-Ah Kim, Sang-Geun Jang, Ja-Lok Ku   +4 more
doaj   +1 more source

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

Nature Reviews Clinical Oncology, 2020
An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal–Anal Task Forces of the United States ...
A. Dasari, V. Morris, C. Allegra, C. Atreya, A. Benson, P. Boland, Ki Chung, M. Copur, R. Corcoran, D. Deming, A. Dwyer, M. Diehn, C. Eng, T. George, M. Gollub, R. Goodwin, Stanley R. Hamilton, J. Hechtman, H. Hochster, T. Hong, F. Innocenti, A. Iqbal, S. Jacobs, H. Kennecke, James J. Lee, C. Lieu, H. Lenz, O. W. Lindwasser, C. Montagut, B. Odisio, F. Ou, Laura D. Porter, K. Raghav, D. Schrag, A. Scott, Q. Shi, J. Strickler, A. Venook, R. Yaeger, G. Yothers, Y. You, J. Zell, S. Kopetz   +42 more
semanticscholar   +1 more source

Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer

JAMA Network Open, 2020
Key Points Question Is total neoadjuvant therapy (TNT) associated with improved outcomes when compared with standard concurrent chemoradiotherapy followed by surgery and adjuvant chemotherapy (CRT plus A) for locally advanced rectal cancer?
A. Kasi, Saqib Abbasi, S. Handa, R. Al-Rajabi, A. Saeed, J. Baranda, Weijing Sun   +6 more
semanticscholar   +1 more source

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.

Cell Stem Cell, 2019
Accumulating evidence indicates that patient-derived organoids (PDOs) can predict drug responses in the clinic, but the ability of PDOs to predict responses to chemoradiation in cancer patients remains an open question. Here we generate a living organoid
Ye Yao, Xiaoya Xu, Li-feng Yang, Ji Zhu, J. Wan, L. Shen, F. Xia, G. Fu, Yun Deng, M. Pan, Q. Guo, Xiaoxue Gao, Yuanchuang Li, X. Rao, Yi Zhou, L. Liang, Yaqi Wang, Jing Zhang, Hui Zhang, G. Li, Lixing Zhang, Junjie Peng, S. Cai, Chen Hu, Jianjun Gao, H. Clevers, Zhen Zhang, Guoqiang Hua   +27 more
semanticscholar   +1 more source

Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer [PDF]

Zhongguo aizheng zazhi
Background and purpose: Tumor microangiogenesis is an important basis for tumor growth and metastasis, and its characteristics include angiogenesis, increased vascular permeability and abnormal capillary structure.
SONG Dan, CHAI Yaxin, GE Yanping
doaj   +1 more source

Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy

JAMA Oncology, 2019
Importance The watch-and-wait (WW) strategy aims to spare patients with rectal cancer unnecessary resection. Objective To analyze the outcomes of WW among patients with rectal cancer who had a clinical complete response to neoadjuvant therapy.
J. Smith, Paul Strombom, O. Chow, Campbell S. Roxburgh, Campbell S. Roxburgh, P. Lynn, A. Eaton, M. Widmar, K. Ganesh, R. Yaeger, A. Cercek, M. Weiser, G. Nash, J. Guillem, Larissa K.F. Temple, Sreedevi Chalasani, J. Fuqua, I. Petkovska, A. Wu, M. Reyngold, E. Vakiani, J. Shia, N. Segal, James D. Smith, C. Crane, M. Gollub, M. Gonen, L. Saltz, J. García-Aguilar, P. Paty   +29 more
semanticscholar   +1 more source

Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy

Clinical Cancer Research, 2020
Purpose: Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. Experimental Design: dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for characteristics ...
A. Cercek, G. dos Santos Fernandes, C. Roxburgh, K. Ganesh, S. Ng, F. Sánchez-Vega, R. Yaeger, N. Segal, D. Reidy‐Lagunes, A. Varghese, A. Markowitz, Chao Wu, Bryan C Szeglin, Charles-Etienne Gabriel Sauvé, E. Salo-Mullen, Christina Tran, Z. Patel, Asha R Krishnan, K. Tkachuk, G. Nash, J. Guillem, P. Paty, J. Shia, N. Schultz, J. García-Aguilar, L. Diaz, K. Goodman, L. Saltz, M. Weiser, J. Smith, Z. Stadler   +30 more
semanticscholar   +1 more source

The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.

PLoS ONE, 2015
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients.
Yu Zhang, Ping-Wu Zhao, Gang Feng, Gang Xie, An-Qun Wang, Yong-Hong Yang, Dong Wang, Xiao-Bo Du   +7 more
doaj   +1 more source

UTILIDAD DEL ULTRASONIDO TRANSRECTAL SIN BALÓN EN LA ESTADIFICACION PREOPERATORIA DEL CÁNCER RECTAL

Revista Chilena de Radiología
Objetivos: Determinar la utilidad del ultrasonido transrectal sin balón (USTRsb) en la estadificación preoperatoria del cáncer rectal. Método: Estudiamos 57 pacientes con diagnóstico de cáncer rectal desde julio 2003 a Julio 2007, a los que se les ...
Lesly Solís A, Raquel Pérez G, Osyari Ipsán M, Ariel Gonzáles L   +3 more
doaj   +1 more source

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2018
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer address diagnosis, staging, surgical management, perioperative treatment, management of recurrent and metastatic disease, disease surveillance, and survivorship in ...
A. Benson, A. Venook, M. Al-Hawary, L. Cederquist, Yi-Jen Chen, K. Ciombor, S. Cohen, H. Cooper, D. Deming, P. Engstrom, J. Grem, A. Grothey, H. Hochster, S. Hoffe, S. Hunt, A. Kamel, Natalie N. Kirilcuk, S. Krishnamurthi, W. Messersmith, J. Meyerhardt, M. Mulcahy, James D. Murphy, Steven J. Nurkin, L. Saltz, Sunil Sharma, D. Shibata, J. Skibber, C. Sofocleous, E. Stoffel, E. Stotsky-Himelfarb, C. Willett, E. Wuthrick, K. Gregory, Lisa A. Gurski, Deborah A. Freedman-Cass   +34 more
semanticscholar   +1 more source