Results 51 to 60 of about 5,139,728 (295)

Análisis de la posible influencia de las lesiones sincrónicas en el pronóstico del cáncer colorrectal resecado [PDF]

, 2008
Aim: To analyze the relationship between synchronous lesions in patients with colorectal cancer and their prognostic value. Patients and methods: We have retrospectively reviewed 369 patients with resected colorectal cancer.
Betes, M.T. (María Teresa), Borda-Celaya, F. (F.), Borda-Martin, A. (Ana), Martinez-Peñuela, J.M. (J.M.), Muñoz-Navas, M. (Miguel), Prieto-Martinez, C. (C.)   +5 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Diagnóstico de cáncer de próstata con un mayor número de muestras tisulares, obtenidas por biopsia transrectal guiada por ecografía en pacientes con indicación de biopsia o rebiopsia, teniendo en cuenta el PSA, tamaño prostático y hallazgos altacto rectal, en pacientes que asistieron al hospital militar central de Bogotá y al dispensario médico Gilberto Echeverry Mejía del Ejército Nacional de Colombia, desde junio de 2008 a junio 2010 [PDF]

, 2013
El estudio pretende demostrar que la biopsia transrectal de próstata guiada por ecografía realizada con el protocolo del Hospital Militar Central de Bogotá y del dispensario Gilberto Echeverry Mejía del Ejercito Nacional de Colombia en Bogotá, que ...
Agresott, Wilmer Alberto, Shek, Álvaro
core  

Factores que influyen en la calidad de vida de pacientes con cáncer de colon y recto [PDF]

, 2010
OBJETIVO: Foi realizada uma revisão integrativa da literatura com o objetivo de avaliar as evidências disponíveis na literatura o conhecimento científico produzido relacionado à qualidade de vida (QV) do paciente adulto com câncer de cólon e reto ...
NICOLUSSI, Adriana Cristina, SAWADA, Namie Okino   +1 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Immunological Landscape and Clinical Management of Rectal Cancer

Frontiers in Immunology, 2016
The clinical management of rectal cancer and colon cancer differs due to increased local relapses in rectal cancer. However, the current molecular classification does not differentiate rectal cancer and colon cancer as two different entities.
Elísabeth ePérez-Ruiz, Pedro eBerraondo   +1 more
doaj   +1 more source

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

JAMA Oncology, 2018
Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been ...
A. Cercek, Campbell S. Roxburgh, Campbell S. Roxburgh, Paul Strombom, J. Smith, L. Temple, G. Nash, J. Guillem, P. Paty, R. Yaeger, Z. Stadler, K. Seier, M. Gonen, N. Segal, D. Reidy, A. Varghese, J. Shia, E. Vakiani, A. Wu, C. Crane, M. Gollub, J. García-Aguilar, L. Saltz, M. Weiser   +23 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial

Journal of Clinical Oncology, 2019
PURPOSE In the multicenter, open-label, phase III FOWARC trial, modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher pathologic complete response rate than fluorouracil plus radiotherapy in ...
Yanhong Deng, P. Chi, P. Lan, Lei Wang, Weiqing Chen, L. Cui, Daoda Chen, Jie Cao, Hongbo Wei, Xiang Peng, Zonghai Huang, Guanfu Cai, R. Zhao, Zhongcheng Huang, Lin Xu, Hongfeng Zhou, Yisheng Wei, Hao Zhang, Jian Zheng, Yan Huang, Zhi-yang Zhou, Yue Cai, L. Kang, Meijin Huang, Xiaojian Wu, J. Peng, D. Ren, Jianping Wang   +27 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source