Results 241 to 250 of about 6,225,903 (287)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Correction: Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care. [PDF]

Br J Cancer
Blanchet B, Xu-Vuillard A, Jouinot A, Puisset F, Combarel D, Huillard O, Le Louedec F, Thomas F, Teixeira M, Flippot R, Mourey L, Albiges L, Pudlarz T, Joly C, Tournigand C, Chauvin J, Puszkiel A, Chatelut E, Decleves X, Vidal M, Goldwasser F, Oudard S, Medioni J, Vano YA.   +23 more
europepmc   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

NF1/2 mutations predict favorable benefit from immune checkpoint inhibitor-based therapies over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma. [PDF]

Clin Exp Med
Sun Y, Cheng Q, Zhou Q, Xu Y, Wang G, Xu C, Wang W, Cai S, Chen W.   +8 more
europepmc   +1 more source

Tumores de vejiga: diagnóstico, clasificación y estadiaje [PDF]

Ferrutxe Frau, Juan, Montserrat Orri, Vicente, Mus Malleu, Alfredo, Ozonas Moragues, Mariano, Sala O'Shea, Enrique   +4 more
core  

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Photon-counting detector CT in oncology: a new era of cancer imaging. [PDF]

Insights Imaging
Bruno E, Palmisano A, Camisassa E, Vignale D, Tacchetti C, Esposito A.   +5 more
europepmc   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Comparative study of eGFR in cancer and non-cancer individuals: a multicenter analysis. [PDF]

Front Med (Lausanne)
Ye B, Luo X, Luo Y, Zhou Z, Jiang B, Xiong L, Peng Y, Zou X, Huang Y, Lin Y, Zhang L, Yang X, Dong P, Liu Y, Yan Y, Liu X, Xie J, Xiao Y, Cui B, Wang S, Lu J, He Z, Liu H, Li J, Li Z, Lu W, Li Y, Liu H, Jia T, Niu L, Zhou F, Yu C, Zhang Z.   +32 more
europepmc   +1 more source

Evaluación de la eficacia Terapéutica y Radiotoxicidad de los conjugados Lu Dota- E-c (RGDfK)y Lu-Dota - GGC - AuNP-c [RGDfK (C)] en un Modelo muriño y su relación con la inhibición de los factores Angiogénicos VEGF y HIF-1 [PDF]

, 2013
Gómez Olivan, Leobardo Manuel, Vilchis Juárez, Andrea   +1 more
core