Results 11 to 20 of about 5,280 (157)

Human Endothelial Cell Seeding in Partially Decellularized Kidneys

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
The excessive demand for organ transplants has promoted the development of strategies that increase the supply of immune compatible organs, such as xenotransplantation of genetically modified pig organs and the generation of bioartificial organs. We describe a method for the partial replacement of rat endothelial cells for human endothelial cells in a ...
Geraldine Haeublein, Gabriela Lombardi, Fiorella Caro, Diego Guerrieri, Carla Remolins, Claudio Incardona, Domingo Casadei, Eduardo Chuluyan, Krzysztof Siemianowicz   +8 more
wiley   +1 more source

Nano‐therapeutic strategies to target coronavirus

VIEW, Volume 2, Issue 3, June 2021., 2021
The role of nanotechnology in the detection and the therapeutics of the COVID‐19. The image was created with biorender.com. Abstract The coronaviruses have caused severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the more recent coronavirus pneumonia (COVID‐19).
Mohd Ahmar Rauf, Munazzah Tasleem, Ketki Bhise, Katyayani Tatiparti, Samaresh Sau, Arun K. Iyer   +5 more
wiley   +1 more source

Supercharged Proteins and Polypeptides

Advanced Materials, Volume 32, Issue 20, May 22, 2020., 2020
Natural proteins with high net charges can be an inspiration for scientists to artificially supercharge other protein entities. Recent findings show that supercharging proteins allows for control of their properties such as temperature resistance and catalytic activity.
Chao Ma, Anke Malessa, Arnold J. Boersma, Kai Liu, Andreas Herrmann   +4 more
wiley   +1 more source

VLPs Derived from the CCMV Plant Virus Can Directly Transfect and Deliver Heterologous Genes for Translation into Mammalian Cells

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Virus‐like particles (VLPs) are being used for therapeutic developments such as vaccines and drug nanocarriers. Among these, plant virus capsids are gaining interest for the formation of VLPs because they can be safely handled and are noncytotoxic.
María V. Villagrana-Escareño, Elizabeth Reynaga-Hernández, Othir G. Galicia-Cruz, Ana L. Durán-Meza, Viridiana De la Cruz-González, Carmen Y. Hernández-Carballo, Jaime Ruíz-García, Lucia Lopalco   +7 more
wiley   +1 more source

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV‐1

Scientifica, Volume 2013, Issue 1, 2013., 2013
Type I interferon (IFN‐I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality ...
Adriano Boasso, G. Chen, M. Clementi
wiley   +1 more source

An Overview on the Field of Micro‐ and Nanotechnologies for Synthetic Peptide‐Based Vaccines

Journal of Drug Delivery, Volume 2011, Issue 1, 2011., 2011
The development of synthetic peptide‐based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide‐based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely.
Aiala Salvador, Manoli Igartua, Rosa Maria Hernández, José Luis Pedraz, Sanyog Jain   +4 more
wiley   +1 more source

Novel Phenazine 5,10‐Dioxides Release •OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo

International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011
Phenazine 5,10‐dioxides (PDOs) are a new class of bioreductive cytotoxins, which could act towards tumours containing hypoxic regions. The PDOs selective‐hypoxic bioreduction was probed in vitro; however, the mechanism of action has not been completely explained. Besides, PDOs in vivo antitumour activities have not been demonstrated hitherto.
María L. Lavaggi, Mauricio Cabrera, Cristina Pintos, Carolina Arredondo, Gisela Pachón, Jorge Rodríguez, Stella Raymondo, José Pedro Pacheco, Marta Cascante, Claudio Olea-Azar, Adela López de Ceráin, Antonio Monge, Hugo Cerecetto, Mercedes González, P. Cos   +14 more
wiley   +1 more source

Gene Therapy for HIV Infections: Intracellular Immunization

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 10, Issue 4, Page 307-312, 1999., 1999
Despite significant advances in the treatment of human immunodeficiency virus (HIV) infection in the past 10 years, it remains an incurable disease. The inability of traditional drug‐based therapies to inhibit HIV replication effectively for extended periods of time has stimulated intense research to develop novel approaches for this disease.
Alain Piché
wiley   +1 more source

Pathogenesis of HSV and CMV Infections in Pregnancy

Infectious Diseases in Obstetrics and Gynecology, Volume 5, Issue 2, Page 133-141, 1997., 1997
Human herpesvirus (HHSV) and human cytomegalovirus (HCMV) infections during pregnancy are a major concern of public health because of the risk for severe sequelae for the fetuses and the neonates and because primary infections, reinfections and reactivations can be asymptomatic. The risk for neonatal herpes is mostly congenital, while the risk for HCMV
Myriam Askienazy-Elbhar, Christophe Sifer   +1 more
wiley   +1 more source

Incidencia de potyvirus y caracterización molecular de PVY en regiones productoras de papa (Solanum tuberosum L.) de Colombia

Revista Colombiana de Biotecnología, 2011
Incidence of potyvirus and molecular characterization of PVY in potato (Solanum tuberosum L.) growing regions of Colombia Título corto: Incidencia de potyvirus en cultivos de papa de Colombia   Resumen Los problemas virales reducen los rendimientos y la
José Miguel Cotes, José Fernando Gil, Mauricio Marín   +2 more
doaj   +2 more sources