Results 191 to 200 of about 10,776,501 (260)

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Alkyl chain elongation engineering: Unlocking high‐brightness NIR‐II O‐xanthene dyes for in vivo bioimaging

Smart Molecules, EarlyView.
O‐xanthene–based fluorophore enhanced fluorescence quantum yield and brightness were achieved by extending the N‐alkyl chain on the aniline donor. Abstract NIR‐II fluorescent probes are powerful tools for advanced imaging, with performance governed by molar extinction coefficient (ε), quantum yield (Φ), and brightness (ε × Φ).
Yu Zhao, Hong Zhang, Ruirui Zhang, Wenli Xia, Zhouyu Wang, Jie Chen, Xiaoqi Yu, Kun Li   +7 more
wiley   +1 more source

Cardiac Resynchronization Therapy in Cardio-Oncology: Real-World Evidence of Benefit in Cancer Patients with Heart Failure. [PDF]

Arq Bras Cardiol
Gregório C, Magalhães A, Silva B, Araújo I, Vilela M, Marques P, Sousa J, Menezes MN, Pinto FJ, Fiuza M.   +9 more
europepmc   +1 more source

Constructing Difference: Maternal Boundary‐Work in Science‐Based and Natural Mom Groups on Facebook

Symbolic Interaction, EarlyView.
Boundary‐work describes the activities of social groups as they seek to differentiate themselves from others to establish credibility, authority, or to protect their interests. While a growing body of literature explores occupational boundary‐work in health care, limited research has focused on how lay actors practice boundary‐work online.
Darryn DiFrancesco
wiley   +1 more source

Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women. [PDF]

Rev Lat Am Enfermagem
Marin FC, Sousa CA, Abuchaim ESV, Silva IA.   +3 more
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Thrombocytosis and tumour distribution predict outcome in dogs with hepatocellular carcinoma: A multi‐institutional retrospective analysis

Veterinary Record, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is the most common canine hepatobiliary tumour. This study aimed to determine which criteria influenced outcome of HCC in a modern population of dogs across eight institutions. Methods The medical records of 106 dogs with HCC were retrospectively reviewed.
Emily A. Janik, MacKenzie A. Pellin, Dawn M. Clarke   +2 more
wiley   +1 more source

Nursing practices in Primary Health Care in rural areas: a scoping review. [PDF]

Rev Bras Enferm
Galvão JR, Fausto MCR, Cabral LMDS, Almeida PF.   +3 more
europepmc   +1 more source