Results 111 to 120 of about 2,071,741 (220)

Molecular Basis of α-Glycine C-H Activation by a Nonheme Fe(II)/2-Oxoglutarate Dioxygenase. [PDF]

Biochemistry
Chen M, Wanniarachchi TN, Caranto JD, Seabra G, Bruner SD, Ding Y.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Formal Diels-Alder reaction of saturated carboxylic acids via C-H activation. [PDF]

Nat Chem
He Q, Lu Y, Sheng T, Chekshin N, Yan JL, Zhang T, Yu JQ.   +6 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation

ACS Omega, 2020
Yuriy A. Kvashnin, Egor V. Verbitskiy, Ekaterina F. Zhilina, Gennady L. Rusinov, Oleg N. Chupakhin, Valery N. Charushin   +5 more
doaj   +1 more source

Iron tris-mesityl: a homoleptic iron(ii) ferrate species for directed C-H activation. [PDF]

Chem Sci
Radović A, Healy MC, Datta A, Das D, Cai L, Diaz S, Gogoi AR, Wolford NJ, Carpenter SH, Brenessel WW, McCamant D, Gutierrez O, Neidig ML.   +12 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Diversity-Oriented C-H Activation Reactions of the Naphthalene Scaffold. [PDF]

J Am Chem Soc
Fan Z, Hoque ME, Wu K, Palkowitz MD, Velaparthi U, Gillman KW, Qiao JX, Yu JQ.   +7 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Correction: Iron tris-mesityl: a homoleptic iron(ii) ferrate species for directed C-H activation. [PDF]

Chem Sci
Radović A, Healy MC, Datta A, Das D, Cai L, Diaz S, Gogoi AR, Wolford NJ, Carpenter SH, Brenessel WW, McCamant D, Gutierrez O, Neidig ML.   +12 more
europepmc   +1 more source