Results 231 to 238 of about 3,837,372 (238)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Na-Promoted Bimetallic Hydroxide Nanoparticles for Aerobic C-H Activation: Catalyst Design Principles and Insights into Reaction Mechanism. [PDF]

ACS Appl Mater Interfaces
Erdivan B, Calikyilmaz E, Bilgin S, Erdali AD, Gul DN, Ercan KE, Türkmen YE, Ozensoy E.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Noncovalent interaction with a spirobipyridine ligand enables efficient iridium-catalyzed C-H activation. [PDF]

Nat Commun
Jin Y, Ramadoss B, Asako S, Ilies L.
europepmc   +1 more source

Enhancing the nucleophilicity of aluminyl anions: targeting selective C-H activation. [PDF]

Chem Sci
Kallmeier F, Nelmes GR, McMullin CL, Edwards AJ, Hicks J.   +4 more
europepmc   +1 more source

CdS Quantum Dot Gels as a Direct Hydrogen Atom Transfer Photocatalyst for C-H Activation. [PDF]

Angew Chem Int Ed Engl
Liu D, Hazra A, Liu X, Maity R, Tan T, Luo L.   +5 more
europepmc   +1 more source

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition-C-H Activation for the In-Flow Synthesis of <i>N</i>-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates. [PDF]

Org Lett
Donato E, Mayorquín-Torres MC, Puglisi A, Benaglia M, Adamo MFA, Stevens CV.   +5 more
europepmc   +1 more source

Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization. [PDF]

Angew Chem Int Ed Engl
Wu K, Lam N, Strassfeld DA, Fan Z, Qiao JX, Liu T, Stamos D, Yu JQ.   +7 more
europepmc   +1 more source