Results 81 to 90 of about 31,239,114 (260)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2021 International audienceAnomeric C-H bond activation is an unsolved long-standing synthetic challenge. Herein we report a diastereoselective Pd-catalyzed anomeric C(sp 3)-H activation methodology that allows the synthesis of elusive C-(hetero ...
Ghouilem, Juba +14 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ruthenium- and Cobalt-Catalyzed C-H Activation [PDF]
, 2018 The thesis contents methods for the ruthenium- and cobalt catalyzed C-H activation of arenes. Ruthenium(II) catalysis was used to alkenylate arylacetamides using acrylates or alkynes.
Bu, Qingqing +5 more
core +1 more source
Exploiting Chemical Diversity through C–H Activation and DNA-Encoding [PDF]
, 2020 DNA-encoded library (DEL) technology has the potential to dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment.
Zhe, Zhuang +13 more
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
ChemistryEuropeHighly selective catalytic C(sp3)−H borylation of methoxy groups has been achieved using newly synthesized iron complexes bearing benzene‐based PCP‐type pincer ligands as catalysts. Reactions of various aryl and alkyl methyl ethers as substrates with bis(
Shogo Kuriyama +3 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Advanced ScienceAryl–aryl coupling at remote C–H sites remain a formidable challenge in organic synthesis, particularly for electronically biased arenes and heteroarenes.
Jagrit Grover +6 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source