Results 81 to 90 of about 28,217,704 (208)

Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

European Journal of Organic Chemistry, EarlyView.
Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori, Luigi Dolcini, Alexander Bell, Joshua P. Barham   +3 more
wiley   +1 more source

Sequential Hydrocarbon Functionalization:  Allylic C−H Oxidation/Vinylic C−H Arylation

, 2016
A Pd(II)/sulfoxide-catalyzed sequential allylic C−H oxidation/vinylic C−H arylation of α-olefins to furnish E-arylated allylic esters in high regio- and E:Z selectivities (>20:1) is reported.
M. Christina White (1315503), Jared H. Delcamp (1431343)   +1 more
core   +2 more sources

Mono or double Pd-catalyzed C–H bond functionalization for the annulative π-extension of 1,8-dibromonaphthalene: a one pot access to fluoranthene derivatives

Beilstein Journal of Organic Chemistry
The Pd-catalyzed annulative π-extension of 1,8-dibromonaphthalene for the preparation of fluoranthenes in a single operation has been investigated. With specific arenes such as fluorobenzenes, the Pd-catalyzed double functionalization of C–H bonds yields
Nahed Ketata, Linhao Liu, Ridha Ben Salem, Henri Doucet   +3 more
doaj   +1 more source

Thermal Nickel‐Catalyzed N‐Arylation of Sulfonimidamides With (Hetero)aryl Chlorides Enabled by PAd‐DalPhos Ligation

European Journal of Organic Chemistry, EarlyView.
The nickel‐catalyzed S═NH N‐arylation of sulfonimidamides is described, with useful demonstrated substrate scope involving inexpensive and widely available (hetero)aryl chloride reaction partners, including the active pharmaceutical ingredient chlorpromazine.
Samuel A. Fisher, Patrick L. DeRoy, Mark Stradiotto   +2 more
wiley   +1 more source

Pd/C-Catalyzed Intramolecular C–H Arylation for the Synthesis of Phenanthridinones and Dibenzo-α-pyrones

SynOpen, 2017
Pd/C was found to be an efficient and convenient metal catalyst for intramolecular C–H arylation reactions in the synthesis of phenanthridinones and dibenzo-α-pyrones. A variety of phenanthridinones and dibenzo-α-pyrones were synthesized under the highly
Lingyu Zhao, Guodong Shen, Tongxin Zhang, Zhen Wang, Yuhua Liang   +4 more
doaj   +1 more source

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C–H Arylation toward Dihydrobenzothienooxepines

, 2018
A practical convergent synthesis of PI3K inhibitor GDC-0908 (1) is described. The process features a dihydrobenzothienooxepine formation via palladium-catalyzed intramolecular direct C–H arylation and a Negishi coupling to construct the key C–C bonds. We
Haiming Zhang, Haiming Zhang (651820), Brian Wong (1520122), Francis Gosselin, Beryl X. Li (3050352), Andreas Stumpf, Beryl X. Li, Andreas Stumpf (1581568), Brian Wong, C. Gregory Sowell (3820372), Francis Gosselin (1442914), C. Gregory Sowell   +11 more
core   +1 more source

Synthesis of Flavones by Intramolecular O‐Arylation of Unactivated Halogenated Aryl‐1,3‐diketones

European Journal of Organic Chemistry, EarlyView.
A protocol for the synthesis of flavone derivatives starting from mono‐ and dihalogenated diketones including fluorinated derivatives in a very simple and effective way is reported. Flavones are an important class of secondary metabolites in plants. Here we report a straightforward method for the conversion of unactivated halogenated 1,3‐biaryl‐1,3 ...
Lena Deutsch, Lucca Pfitzer, Adam H. Day, Rachel A. Buschmann, Vanessa Raisch, Maximilian Kirchner, Samuel P. Jones, Johannes Kästner, Anke Krueger   +8 more
wiley   +1 more source

Regioselective Pd-catalyzed direct C1- and C2-arylations of lilolidine for the access to 5,6-dihydropyrrolo[3,2,1-ij]quinoline derivatives

Beilstein Journal of Organic Chemistry, 2019
The Pd-catalyzed C–H bond functionalization of lilolidine was investigated. The use of a palladium-diphosphine catalyst associated to acetate bases in DMA was found to promote the regioselective arylation at α-position of the nitrogen atom of lilolidine ...
Hai-Yun Huang, Haoran Li, Thierry Roisnel, Jean-François Soulé, Henri Doucet   +4 more
doaj   +1 more source

Synthesis of a 1,2-Dithienylethene-Containing Donor-Acceptor Polymer via Palladium-Catalyzed Direct Arylation Polymerization (DArP)

Molecules, 2018
This paper reports the synthesis of D-A polymers containing 1,2-dithienylethene (DTE) units via palladium-catalyzed direct arylation polymerization (DArP).
Masayuki Wakioka, Natsumi Yamashita, Hiroki Mori, Yasushi Nishihara, Fumiyuki Ozawa   +4 more
doaj   +1 more source

β‑Selective C–H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I

, 2016
The first general β-selective C–H arylation of pyrroles has been developed by using a rhodium catalyst. This C–H arylation reaction, which is retrosynthetically straightforward but results in unusual regioselectivity, could result in de novo syntheses of
Kirika Ueda (1746433), Richard M. Maceiczyk (1746436), Kazuma Amaike (1344300), Junichiro Yamaguchi (1685833), Kenichiro Itami (1578556)   +4 more
core   +1 more source